Designing New Evolutionary Algorithms for Parameter Estimation

Mike Gaiewski

Mentor: Jacqueline Dresch

One of the most important steps in mathematical modeling of a biological system is fitting the parameters of your model to experimental data. There is an extremely large number of different parameter estimation algorithms available, and an important question to ask is: what parameter estimation method should be used on my particular problem? In an attempt to answer this question in the context of modeling gene regulation, Michael developed and implemented novel parameter estimation algorithms based on the principles of evolution.