Biologically-Based Risk Modeling with a Focus on Cellular Repair Mechanisms
for Radiation-Induced Damage

Principal Investigator: Robert L. Goble

Ionizing radiation holds a special place among environmental carcinogens because of the extent of information available about radiation effects on humans, on other animals, and on cells and cell systems. The information available has been enhanced recently with the availability of new genetic assays that shed light on both low dose effects and the rates of processes, such as DNA repair, that can modify the expected incidence of effects at low doses and dose rates. With so much information available along with very substantial ongoing research efforts, now is a propitious time to attempt syntheses in the form of biologically based risk models.

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