{"id":921,"date":"2024-12-19T10:30:48","date_gmt":"2024-12-19T15:30:48","guid":{"rendered":"https:\/\/www.golive.clarku.edu\/faculty\/profiles\/arundhati-nag\/"},"modified":"2026-04-05T19:09:27","modified_gmt":"2026-04-05T23:09:27","slug":"arundhati-nag","status":"publish","type":"cu_faculty","link":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/","title":{"rendered":"Arundhati Nag"},"content":{"rendered":"

Professor Nag’s lab develops unique peptide or peptidomimetic macrocycles using robust chemical reactions and Solid Phase Peptide Synthesis. Macrocycles, with molecular weights of approximately 1000, bridge the gap between small molecules and proteins, in terms of size and composition. Chemical synthesis of macrocycles allows one to incorporate unique properties such as thermal and protease stability and inclusion of small molecules. Harnessing the power of molecular recognition in macrocycles, we currently are working on different aspects of biological chemistry and catalysis.<\/p>\n

Currently her group is focused on the following themes:<\/p>\n

1. Macrocyclic peptides as potential Cancer Therapeutics Intracellular regulatory proteins involved in cell signaling frequently interact with each other through large surface areas, a phenomenon termed as Protein Protein Interactions (PPi), and aberrant PPI can lead to diseases like cancer. Peptide macrocycles, with their extended structures, can occupy efficiently the large protein surfaces involved in PPI, and therefore can inhibit prevent aberrant intracellular PPI. The Nag lab is developing a technology to synthesize and screen novel peptide macrocycles which can penetrate the cell membranes and selective target the protein interaction surfaces.<\/p>\n

2. Designing biomimetic catalytic centers<\/p>\n

Complexes of transition metals like copper and nickel with peptide and peptidomimetic macrocycles can be visualized as miniature versions of photosynthetic proteins such as Photosystem I and Photosystem II. While the proteins are excellent catalysts, they degrade rapidly outside the cellular environment. The Nag Lab is trying to optimize the motifs of known linear peptides, as complexes with metals, for efficiency as water oxidation catalysts. Future work will involve development of unique macrocycle \u2013metal or organic ligand – metal catalytic centers as catalysts for homogeneous and heterogeneous water oxidation and carbon dioxide reactions.<\/p>\n

3. Developing biological small molecule sensors<\/p>\n

Building on our previous research on selective recognition of phospho-serine and phosphorylated proteins, we plan to develop macrocyclic reagents for recognition of phosphate containing biological small molecules. Selective recognition will involve not only the phosphate moiety sensing but also unique sensing of other parts of the small molecule. Unique elements in the macrocycles will enable phosphate recognition while amino acid components of the macrocycle will allow selective recognition of the small molecule.<\/p>\n","protected":false},"author":0,"featured_media":1936,"parent":0,"template":"","meta":{"cu_faculty_f180_userid":"C70252069","cu_faculty_first_name":"Arundhati","cu_faculty_last_name":"Nag","cu_faculty_employment_status":"Full Time","cu_faculty_rank":"Associate Professor","cu_faculty_position":"Associate Professor","cu_faculty_phone":"","cu_faculty_email":"ANag@clarku.edu","cu_faculty_location":"","cu_faculty_about":"

Professor Nag's lab develops unique peptide or peptidomimetic macrocycles using robust chemical reactions and Solid Phase Peptide Synthesis. Macrocycles, with molecular weights of approximately 1000, bridge the gap between small molecules and proteins, in terms of size and composition. Chemical synthesis of macrocycles allows one to incorporate unique properties such as thermal and protease stability and inclusion of small molecules. Harnessing the power of molecular recognition in macrocycles, we currently are working on different aspects of biological chemistry and catalysis.<\/p>\n

Currently her group is focused on the following themes:<\/p>\n

1. Macrocyclic peptides as potential Cancer Therapeutics Intracellular regulatory proteins involved in cell signaling frequently interact with each other through large surface areas, a phenomenon termed as Protein Protein Interactions (PPi), and aberrant PPI can lead to diseases like cancer. Peptide macrocycles, with their extended structures, can occupy efficiently the large protein surfaces involved in PPI, and therefore can inhibit prevent aberrant intracellular PPI. The Nag lab is developing a technology to synthesize and screen novel peptide macrocycles which can penetrate the cell membranes and selective target the protein interaction surfaces.<\/p>\n

2. Designing biomimetic catalytic centers<\/p>\n

Complexes of transition metals like copper and nickel with peptide and peptidomimetic macrocycles can be visualized as miniature versions of photosynthetic proteins such as Photosystem I and Photosystem II. While the proteins are excellent catalysts, they degrade rapidly outside the cellular environment. The Nag Lab is trying to optimize the motifs of known linear peptides, as complexes with metals, for efficiency as water oxidation catalysts. Future work will involve development of unique macrocycle \u2013metal or organic ligand - metal catalytic centers as catalysts for homogeneous and heterogeneous water oxidation and carbon dioxide reactions.<\/p>\n

3. Developing biological small molecule sensors<\/p>\n

Building on our previous research on selective recognition of phospho-serine and phosphorylated proteins, we plan to develop macrocyclic reagents for recognition of phosphate containing biological small molecules. Selective recognition will involve not only the phosphate moiety sensing but also unique sensing of other parts of the small molecule. Unique elements in the macrocycles will enable phosphate recognition while amino acid components of the macrocycle will allow selective recognition of the small molecule.<\/p>","cu_faculty_degrees":"Ph.D. in Chemistry,<\/span> California Institute of Technology, 2013\nM.S. in Chemistry,<\/span> Indian Institute of Technology, 2006\nB.S. in Chemistry,<\/span> Presidency College, University of Calcutta, 2004","cu_faculty_cv":"https:\/\/faculty180.interfolio.com\/public\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zT21qREtJZEdWZ0RoSnd5bmhjUjZ2VU4xY1BKSWtUdytqQTYwWDQ5TXpkZ2JscVlsMFg5QnV1aFlCSm1Zak12dz09","cu_faculty_links":"[]","cu_faculty_scholarly_interests":"","cu_faculty_scholarly_works":"[{\"activityid\":10253,\"fields\":{\"Type\":\"Chapters in Books\",\"Chapter Title\":\"<span style="font-size:12pt;">Tetrazine cyclized library for One-Bead-One-Compound library: synthesis and sequencing<\\\/span><span style="font-size:medium;"><\\\/span>\",\"Book Title\":\"Peptide and Peptide Mimicking Tools: Synthesis and Methods\",\"Series Title\":\" Methods in Enzymology\",\"Year\":2024,\"Date Published\":\"\",\"Publisher\":\"Elsevier\",\"Publisher City and State\":\"\",\"Country of Publisher\":\"\",\"Edition\":\"\",\"Page Numbers\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":10253,\"status\":\"In Press\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":5,\"completionorder\":5}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Samir Das\",\"Arundhati Nag\"],\"sort_date\":\"2024-01-01\"},{\"activityid\":10258,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"<p style="text-align:justify;"><span style="font-size:12px;">Water oxidation catalysis properties of copper complex with N-methylated gly4 peptide in an oxidative environment in buffer solution<\\\/span><\\\/p>\",\"Journal Title\":\"Chem Comm\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":10258,\"status\":\"In Progress\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":1,\"completionorder\":1}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"David Lukacs\",\"Qurrat Ul-Ain\",\"Samir Das\",\"Joseph Pap\",\"Arundhati Nag\"],\"sort_date\":\"2024-01-01\"},{\"activityid\":10958,\"fields\":{\"Type\":\"Chapters in Books\",\"Chapter Title\":\"Tetrazine cyclized peptides for one-bead-one-compound library: Synthesis and sequencing\",\"Book Title\":\"\",\"Series Title\":\"Methods in Enzymology\",\"Year\":2024,\"Date Published\":\"\",\"Publisher\":\"Academic Press\",\"Publisher City and State\":\"\",\"Country of Publisher\":\"\",\"Edition\":\"\",\"Page Numbers\":\"\",\"ISSN\":\"0076-6879\",\"DOI\":\"https:\\\/\\\/doi.org\\\/10.1016\\\/bs.mie.2024.04.015\",\"CoAuthor\":null,\"URL\":\"https:\\\/\\\/www.sciencedirect.com\\\/science\\\/article\\\/pii\\\/S0076687924001393\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":10958,\"status\":\"In Press\",\"term\":\"May\",\"year\":2024,\"termid\":\"2023\\\/04\",\"listingorder\":5,\"completionorder\":5}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Samir Das\",\"Arundhati Nag\"],\"sort_date\":\"2024-01-01\"},{\"activityid\":6145,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Engineering of cyclic peptides for cell penetration\",\"Journal Title\":\"Acs Chemical Biology\",\"Series Title\":\"\",\"Month \\\/ Season\":\"Spring\",\"Year\":2024,\"Publisher\":\"ACS\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":6145,\"status\":\"In Progress\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":1,\"completionorder\":1},{\"id\":6145,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2023,\"termid\":\"2022\\\/05\",\"listingorder\":1,\"completionorder\":1},{\"id\":6145,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2022,\"termid\":\"2021\\\/05\",\"listingorder\":1,\"completionorder\":1}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Chi Nguyen\",\"Chen Jue\",\"Arundhati Nag\"],\"sort_date\":\"2024--01\"},{\"activityid\":8812,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"<span style="font-size:12pt;">Development of immobilized copper-ligand complex for click chemistry of biomolecules<\\\/span>\",\"Journal Title\":\"Molecules\",\"Series Title\":\"\",\"Month \\\/ Season\":\"Spring\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"<span>Copper-catalyzed azide-alkyne cycloaddition click reaction is widely used to synthesize drug candidates and various other biomolecules. Homogeneous catalysts, which consist of copper co-ordinated to a ligand framework, have been optimized for high yield and specificity of the Cu-AAC reaction, but CuAAC reaction with these catalysts requires the addition of a reducing agent and basic conditions, which can complicate some of the desired syntheses. Additionally, remov-ing copper from the synthesized CuAAC-containing biomolecule is necessary for biological ap-plications but inconvenient and requires additional purification steps. We describe here the de-sign and synthesis of a PNN-type pincer ligand complex with copper (I) that stabilizes the copper (I) and, therefore, can act as a CuAAC catalyst without a reducing agent and base under physio-logically relevant conditions. This complex was immobilized on two types of resin, and one of the immobilized catalyst forms worked well under aqueous physiological conditions. Minimal cop-per leaching was observed from the immobilized catalyst, which allowed its use in multiple re-action cycles without the addition of any reducing agent or base and without recharging with copper ion. This catalyst's utility was demonstrated by synthesizing coumarin derivatives of small molecules such as ferrocene and sugar.<\\\/span>\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":8812,\"status\":\"Submitted\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":2,\"completionorder\":2},{\"id\":8812,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2023,\"termid\":\"2022\\\/05\",\"listingorder\":1,\"completionorder\":1}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Rene Kandler\",\"Y Benaragama\",\"Manoranjan Bera\",\"Caroline Wang\",\"Rasheda A Samiha\",\"Samir Das\",\"WMC Sameera\",\"Arundhati Nag\"],\"sort_date\":\"2024--01\"},{\"activityid\":8813,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"<span style="color:#0a0a0a;font-size:13px;background-color:#fefefe;">A copper-selective sensor and its inhibition of copper-amyloid beta aggregation<\\\/span>\",\"Journal Title\":\"Biosensors\",\"Series Title\":\"\",\"Month \\\/ Season\":\"Spring\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"<span>opper is an essential trace metal for biological processes in humans and animals. A low level of copper detection at physiological pH using fluorescent probes is very important for in vitro applications, such as the detection of copper in water or urine, and in vivo applications, such as tracking the dynamic copper concentrations inside cells. Copper homeostasis is disrupted in neurological diseases like Alzheimer\\u2019s disease, and copper forms aggregates with amyloid beta (Ab42) peptide, resulting in senile plaques in Alzheimer\\u2019s brains. Therefore, a selective copper detector probe that can detect amyloid beta peptide-copper aggregates and decrease the aggregate size has potential uses in medicine. We have developed a series of Cu2+-selective low fluorescent to high fluorescent tri and tetradentate dentate ligands and conjugated them with a peptide ligand to amyloid- beta binding peptide to increase the solubility of the compounds and make the resultant compounds bind to Cu2+-amyloid aggregates. The copper selective compounds were developed using chemical scaffolds known to have high affinity and selectivity for Cu2+, and their conjugates with peptides were tested for affinity and selectivity towards Cu2+. The test results were used to inform further improvement of the next compound. The final Cu2+ chelator-peptide conjugate we developed shows high selectivity for Cu2+ and high fluorescence properties. The compound bound 1:1 to Cu2+ ion, as determined from its Jobs plot. Fluorescence of the ligand can be detected at nanomolar concentrations. The effect of this ligand on controlling Cu2+ - Ab42 aggregation was studied using fluorescence assays and microscopy. It was found that the Cu2+ -chelator-peptide conjugate efficiently reduced aggregate size and, therefore, acted as an inhibitor of Ab42- Cu2+ aggregation. Since high micromolar concentrations of Cu2+ are present in senile plaques, and Cu2+ accelerates the formation of toxic soluble aggregates of Ab42, which are precursors of insoluble plaques, the developed hybrid molecule can potentially serve as a therapeutic for Alzheimer\\u2019s disease.<\\\/span>\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":8813,\"status\":\"Submitted\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":2,\"completionorder\":2},{\"id\":8813,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2023,\"termid\":\"2022\\\/05\",\"listingorder\":1,\"completionorder\":1},{\"id\":8813,\"status\":\"In Progress\",\"term\":\"May\",\"year\":2023,\"termid\":\"2022\\\/04\",\"listingorder\":1,\"completionorder\":1}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Ngoc K Nguyen\",\"Bella Poduska\",\"Mia Franks\",\"Manoranjan Bera\",\"Ian McCormack\",\"Guoxing Lin\",\"Alexander J Petroff\",\"Samir Das\",\"Arundhati Nag\"],\"sort_date\":\"2024--01\"},{\"activityid\":10943,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Development of Novel Immobilized Copper-Ligand Complex for Click Chemistry of Biomolecules\",\"Journal Title\":\"Molecules\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2024\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"29\",\"Issue Number \\\/ Edition\":\"9\",\"Page Number(s) or Number of Pages\":\"16\",\"ISSN\":\"\",\"DOI\":\"https:\\\/\\\/doi.org\\\/10.3390\\\/molecules29092148\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":10943,\"status\":\"Completed\\\/Published\",\"term\":\"May\",\"year\":2024,\"termid\":\"2023\\\/04\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70252069\",\"attachments\":[{\"attachmentid\":9490,\"mimetype\":\"application\\\/pdf\",\"filename\":\"molecules-29-02148-with-cover.pdf\",\"filesize\":1998304,\"downloadurl\":\"https:\\\/\\\/faculty180.interfolio.com\\\/public\\\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zT21qREtJZEdWZ1JqUjZjYzBLcGFjUHFmWEJzS251aHlyKzUwTUg0UDAxZFNHNDh3VUM3REt0bnB1aTkrTlYyQTJXN3JhekJXYnlmTEZOK1hqZVcybz0%3D\"}],\"coauthors_list\":[\"Rene Kandler\",\"Yomal Benaragama\",\"Manoranjan Bera\",\"Caroline Wang\",\"Rasheda A. Samiha\",\"W. Sameera\",\"Samir Das\",\"Arundhati Nag\"],\"sort_date\":\"2024--01\"},{\"activityid\":10957,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"A Copper-Selective Sensor and Its Inhibition of Copper-Amyloid Beta Aggregation\",\"Journal Title\":\"Biosensors\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2024\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"14\",\"Issue Number \\\/ Edition\":\"5\",\"Page Number(s) or Number of Pages\":\"247\",\"ISSN\":\"\",\"DOI\":\" https:\\\/\\\/doi.org\\\/10.3390\\\/bios14050247\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":10957,\"status\":\"Completed\\\/Published\",\"term\":\"May\",\"year\":2024,\"termid\":\"2023\\\/04\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70252069\",\"attachments\":[{\"attachmentid\":9500,\"mimetype\":\"application\\\/pdf\",\"filename\":\"biosensors-14-00247.pdf\",\"filesize\":4833043,\"downloadurl\":\"https:\\\/\\\/faculty180.interfolio.com\\\/public\\\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zT21qREtJZEdWZzVnSmVPcmJPU3VuczNrQmtSUHQvQ1lmekhzSXdVNHhEUDFJZXR1aW1QZWJ4YTJHcHlKQzlhZz09\"}],\"coauthors_list\":[\"Ngoc Kim Nguyen\",\"Bella Poduska\",\"Mia Franks\",\"Manoranjan Bera\",\"Ian MacCormack\",\"Guoxing Lin\",\"Alexander P. Petroff\",\"Samir Das\",\"Arundhati Nag\"],\"sort_date\":\"2024--01\"},{\"activityid\":6143,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Stereochemical engineering of a peptide macrocycle allosteric inhibitor of phospho-Akt2 controls cell penetration by fine-tuning macrocycle-cell membrane interactions\",\"Journal Title\":\"Communications Chemistry\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2023,\"Publisher\":\"Nature\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"https:\\\/\\\/doi.org\\\/10.1038\\\/s42004-023-00890-w\",\"CoAuthor\":null,\"URL\":\"https:\\\/\\\/www.nature.com\\\/articles\\\/s42004-023-00890-w\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":6143,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2023,\"termid\":\"2022\\\/03\",\"listingorder\":6,\"completionorder\":6},{\"id\":6143,\"status\":\"Submitted\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":2,\"completionorder\":2}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Arundhati Nag\",\"Amirhossein Mafi\",\"Samir Das\",\"Mary Yu\",\"Belen Alvarez-Villalonga\",\"Soo-Kyung Kim\",\"William Goddard\",\"Heath James\"],\"sort_date\":\"2023-1-01\"},{\"activityid\":6146,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Facile de novo sequencing of Tetrazine-cyclized peptide library through one-step ring-opening\\\/cleave reaction\",\"Journal Title\":\"Chembiochem\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2023,\"Publisher\":\"Wiley\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"https:\\\/\\\/chemistry-europe.onlinelibrary.wiley.com\\\/doi\\\/10.1002\\\/cbic.202200590\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":6146,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2023,\"termid\":\"2022\\\/03\",\"listingorder\":6,\"completionorder\":6},{\"id\":6146,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2022,\"termid\":\"2021\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Ariane Borges\",\"Chi Nguyen\",\"Madison Letendre\",\"Iryna Onasenko\",\"Amy Chen\",\"Tamara Allakhorva\",\"Kim Nguyen\",\"Bella DiChiara\",\"Caroline Wang\",\"Henna Patel\",\"Emily Atkinson\",\"Arundhati Nag\"],\"sort_date\":\"2023-1-01\"},{\"activityid\":6144,\"fields\":{\"Type\":\"Articles in Non-Refereed Journals\",\"Title\":\"<p><span style="font-size:17px;">A library of copper-peptide\\\/peptidomimetic complexes to explore the effect of ligand framework modification on electrocatalytic water oxidation\\u00a0<\\\/span><\\\/p>\",\"Journal Title\":\"\",\"Series Title\":\"\",\"Month \\\/ Season\":\"Fall\",\"Year\":2023,\"Publisher\":\"ChemRxiv \",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"10.26434\\\/chemrxiv-2024-bpvvq\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"<span>Inspired by the process of water oxidation during photosynthesis, researchers have developed mononuclear and polynuclear transition metal complexes as homogeneous water oxidation catalysts. While water oxidation catalysis by mononuclear copper-peptide complexes with N4 motif has been briefly explored, there is limited research on how systematically changing individual components of the ligand framework can enhance water oxidation catalysis. We report the synthesis and characterization of a library of twenty-eight copper (II) peptide\\\/peptidomimetic complexes, each incorporating a systematic ligand framework change. Their electrocatalytic water oxidation properties were investigated through cyclic voltammetry studies in a pH 11 buffer medium. These studies offer novel insight into how to enhance the water oxidation catalysis abilities of mononuclear and polynuclear copper-peptide\\\/peptidomimetic complexes by modifying the ligand framework.<\\\/span>\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":6144,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2023,\"termid\":\"2023\\\/01\",\"listingorder\":6,\"completionorder\":6},{\"id\":6144,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2023,\"termid\":\"2022\\\/05\",\"listingorder\":1,\"completionorder\":1},{\"id\":6144,\"status\":\"In Progress\",\"term\":\"Summer\",\"year\":2022,\"termid\":\"2021\\\/05\",\"listingorder\":1,\"completionorder\":1}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Qurrat Ul-Ain\",\"Samir Das\",\"Nguyen Kim\",\"Bella Poduska\",\"McAuliffe Molly\",\"Mia Franks\",\"Greenaway Fred\",\"Atkinson Emily\",\"Onasenko Iryna\",\"Rene Kandler\",\"Cramer Wesley\",\"Arundhati Nag\"],\"sort_date\":\"2023--01\"},{\"activityid\":3973,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Copper ligand clusters dictate size of cyclized peptide formed during alkyne azide cycloaddition on solid support\",\"Journal Title\":\"RSC Adv.\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2021,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"11\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"4842-4852\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"BibTeX\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":3973,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2021,\"termid\":\"2021\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"Rene Kandler\",\"Samir 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solutions\",\"Journal Title\":\"Journal of Chemical Sciences\",\"Series Title\":null,\"Month \\\/ Season\":null,\"Year\":2008,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"120\",\"Issue Number \\\/ Edition\":\"1\",\"Page Number(s) or Number of Pages\":\"71--77\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":null,\"Include description in output citation\":0,\"Origin\":\"BibTeX\"},\"facultyid\":\"C70252069\",\"status\":[{\"id\":4100,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2008,\"termid\":\"2008\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70252069\",\"attachments\":[],\"coauthors_list\":[\"A Nag\",\"D Chakraborty\",\"A Chandra\"],\"sort_date\":\"2008-9-01\"}]","cu_faculty_awards_and_grants":"[{\"activityid\":3702,\"fields\":{\"Title\":\"CAREER: Macrocyclic Peptidomimetic Scaffolds for Sensing of Phosphate-containing Metabolites\",\"Sponsor\":\"National Science Foundation\",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2022-10-01\",\"End Date\":\"2027-09-30\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":1,\"Indirect Cost Rate\":\"50.3\",\"Total Funding\":\"690005\",\"Total Direct Funding\":\"0\",\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"\",\"Number of 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- Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":5,\"completionorder\":3}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2027-09-30\"},{\"activityid\":3700,\"fields\":{\"Title\":\"CAREER:Macrocyclic Peptidomimetic Scaffolds for Sensing of Phosphate-containing Metabolites\",\"Sponsor\":\"National Science Foundation\",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2024-10-01\",\"End Date\":null,\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":1,\"Indirect Cost Rate\":\"50\",\"Total Funding\":\"784546\",\"Total Direct Funding\":\"0\",\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"<p>Deregulation of metabolite signaling is implicated in numerous human diseases, and monitoring variations\\u00a0in metabolite concentrations is crucial to understand biological processes. Various metabolic pathways use\\u00a0phosphate to form intermediate metabolites. By monitoring phosphate-containing metabolites in a spatially\\u00a0resolved muti-omics platform, one can visualize if cells are utilizing metabolic pathways like glycolysis to\\u00a0different extents. Therefore, there is an urgent need to develop sensors that can be used for spatial sensing\\u00a0of metabolites in single-cell populations, to yield valuable knowledge about the variations of metabolites at\\u00a0the single-cell level. When obtained in parallel to the spatial single-cell transcriptome, proteome, and\\u00a0genome information, this information can provide unprecedented detail of metabolite movement in single\\u00a0cells. Our objective is to rationalize the design of macrocyclic peptidomimetics as phosphate-containing\\u00a0metabolite sensors, develop fluorescent cyclic peptides metabolite sensors, and use these sensors to\\u00a0visualize the high rates of glycolysis in cancer cells spatially. We propose developing peptidomimetic\\u00a0libraries for two classes of phosphate-containing metabolites \\u2013 nucleotide and sugar metabolite glucose-6-\\u00a0phosphate - and identify selective sensors for ATP, AMP, and G6P through a selective screening\\u00a0technology. We hypothesize that combining metabolite binding motifs found in protein crystal structures\\u00a0with guanidinium motifs in cyclic peptidomimetics will allow selective sensing of phosphate-containing\\u00a0nucleotides. Varying the cycle size will allow selective sensing of different metabolites. These sensors will\\u00a0be incorporated into a well-developed multi-omics platform, enabling real-time spatial metabolite mapping\\u00a0in parallel with spatial transcriptome and proteome analysis.<\\\/p>\",\"Number of Periods\":5,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"6423\":{\"id\":6423,\"grantid\":3700,\"fundedamount\":\"147108\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2024-10-01\",\"enddate\":\"2025-10-01\"},\"6424\":{\"id\":6424,\"grantid\":3700,\"fundedamount\":\"155373\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2025-10-01\",\"enddate\":\"2026-10-01\"},\"6425\":{\"id\":6425,\"grantid\":3700,\"fundedamount\":\"155953\",\"yearfunded\":3,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2026-10-01\",\"enddate\":\"2027-10-01\"},\"6426\":{\"id\":6426,\"grantid\":3700,\"fundedamount\":\"162656\",\"yearfunded\":4,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2027-10-01\",\"enddate\":\"2028-10-01\"},\"6427\":{\"id\":6427,\"grantid\":3700,\"fundedamount\":\"163456\",\"yearfunded\":5,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2028-10-01\",\"enddate\":\"2029-10-01\"},\"6428\":{\"id\":6428,\"grantid\":3700,\"fundedamount\":\"0\",\"yearfunded\":1,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2024-10-01\",\"enddate\":\"2025-10-01\"},\"6429\":{\"id\":6429,\"grantid\":3700,\"fundedamount\":\"0\",\"yearfunded\":2,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2025-10-01\",\"enddate\":\"2026-10-01\"},\"6430\":{\"id\":6430,\"grantid\":3700,\"fundedamount\":\"0\",\"yearfunded\":3,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2026-10-01\",\"enddate\":\"2027-10-01\"},\"6431\":{\"id\":6431,\"grantid\":3700,\"fundedamount\":\"0\",\"yearfunded\":4,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2027-10-01\",\"enddate\":\"2028-10-01\"},\"6432\":{\"id\":6432,\"grantid\":3700,\"fundedamount\":\"0\",\"yearfunded\":5,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2028-10-01\",\"enddate\":\"2029-10-01\"}},\"coauthors\":{\"5956\":{\"authorid\":5956,\"grantid\":3700,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":3700,\"status\":\"Submitted - Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":5,\"completionorder\":3},{\"grantid\":3700,\"status\":\"Submitted for Review\",\"statuslabel\":\"Submitted for Review\",\"term\":\"Summer\",\"year\":2023,\"termid\":\"2022\\\/05\",\"listingorder\":2,\"completionorder\":2}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2024-10-01\"},{\"activityid\":1884,\"fields\":{\"Title\":\"NSF LEAPS-MPS: Macrocyclic Peptidomimetic Scaffolds for Sensing of Phosphate-containing Metabolites\",\"Sponsor\":\"National Science Foundation\",\"Grant ID \\\/ Contract ID\":\" 2213425\",\"Award Date\":\"2022-04-04\",\"Start Date\":\"2022-09-30\",\"End Date\":\"2024-09-30\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":1,\"Indirect Cost Rate\":\"50.3\",\"Total Funding\":\"249923\",\"Total Direct Funding\":\"166283\",\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"<p><span>his award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Arundhati Nag and her students at Clark University, Worcester, MA will work on designing sensors for phosphate-containing metabolites. Metabolic pathways such as glycolysis use phosphate to form intermediate metabolites, and the levels of the phosphate containing metabolites can provide important information implicated in human diseases such as cancer. The Nag lab will focus on developing sensors for adenosine triphosphate, a nucleoside phosphate metabolite, and for glucose-6-phosphate, a sugar phosphate metabolite, which belong to two different important classes of phosphate-containing metabolites. Underrepresented minority (URM) students will be involved in this research, through summer fellowship and directed studies with Professor Nag. Prof. Nag will also be involved in developing a community of URM students at Clark University thorough mingles, and she and her students will participate in outreach activities and develop workshops for regional high schools.<\\\/span><br><br><span>Professor Nag will develop a comprehensive approach for sensing phosphate-containing metabolites by targeting simultaneously both the phosphate moiety and the nucleoside or sugar component attached to the phosphate. The binding motifs will be assimilated into cyclic fluorescent peptidic or peptidomimetic libraries. The libraries will be designed such that they can be easily converted in a one-step reaction to linear analogs that can be readily sequenced using de novo sequencing. The cyclic libraries will be screened for selectively binding the phosphate-containing metabolite of interest, and the hits from the screen, once sequenced, will be studied to help understand which interactions of the sensor with a metabolite are critical for selective detection of metabolites.<\\\/span><\\\/p>\",\"Number of Periods\":2,\"URL\":\"https:\\\/\\\/www.nsf.gov\\\/awardsearch\\\/showAward?AWD_ID=2213425&HistoricalAwards=false\"},\"facultyid\":\"C70252069\",\"funding\":{\"6434\":{\"id\":6434,\"grantid\":1884,\"fundedamount\":\"123327\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2022-09-30\",\"enddate\":\"2023-09-30\"},\"6435\":{\"id\":6435,\"grantid\":1884,\"fundedamount\":\"126596\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2023-09-30\",\"enddate\":\"2024-09-30\"},\"6436\":{\"id\":6436,\"grantid\":1884,\"fundedamount\":\"82054\",\"yearfunded\":1,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2022-09-30\",\"enddate\":\"2023-09-30\"},\"6437\":{\"id\":6437,\"grantid\":1884,\"fundedamount\":\"84229\",\"yearfunded\":2,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2023-09-30\",\"enddate\":\"2024-09-30\"}},\"coauthors\":{\"5958\":{\"authorid\":5958,\"grantid\":1884,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":1884,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":3,\"completionorder\":5},{\"grantid\":1884,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":3,\"completionorder\":5}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2024-09-30\"},{\"activityid\":334,\"fields\":{\"Title\":\"Development of a novel proximity-catalyzed Chemical Epitope Targeting technology for isolating macrocyclic peptide inhibitors of KRas (G12V)- Sos interaction\",\"Sponsor\":\"National Institute of Health\",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2020-09-01\",\"End Date\":\"2024-08-31\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":1,\"Indirect Cost Rate\":\"50\",\"Total Funding\":\"450861\",\"Total Direct Funding\":\"299975.01\",\"Currency Type\":\"USD\",\"Description\":\"

Protein function modifications for therapeutic purposes are typically accomplished with small molecule drugs that bind in deep hydrophobic pockets of proteins. For protein-protein interactions occurring over an extended shallow area, it is challenging to have small molecules binding to the surface area and thereby affecting protein functions. Ras-Sos is a classic example of extensive protein-protein surface interaction, and therefore it remains challenging to inhibit KRas- Sos interactions. KRas is activated by Sos, and it is critical to develop technologies to inhibit interactions of oncogenic mutant KRas with Sos selectively. One such promising technology is the Chemical Epitope Targeting technology, developed for designing peptide ligands with high affinity and specificity against specific regions of an intracellular protein that may be inaccessible to small molecules or antibodies. This technology involves using proximity-catalyzed reaction for screening a specific region of the target protein to isolate peptide ligands.<\\\/p>\\n

The PI proposes to streamline this technology to make it more accessible and user-friendly, and then to tailor this technology to successfully target mutant KRas(G12V) protein, specifically at the Ras-Sos interface. The technology will be streamlined by developing and characterizing synthetic macrocyclic one-bead-one compound (OBOC) peptide libraries that can be cleaved by one-step light exposure for seamless sequencing by tandem Mass Spectrometry (MS\\\/MS) (Aim 1). Inverse Electron Demand Diels Alder (IEDDA) reaction between tetrazine and alkyne will be used for the screening process rather than the currently used azide-alkyne cycloaddition.<\\\/p>\\n

The PI shall demonstrate, as a proof-of-concept, that IEDDA reaction between substituted tetrazine and an alkene can be proximity-catalyzed by a protein. KRas(G12C) or KRas mutants with one Cys will be modified at Cys with tetrazine. The labeling of the complex with an alkene containing Sos-helix peptide, known to bind at the Ras- Sos interface, will be monitored using tandem Mass Spectrometry (Aim 2). The optimal temperature for minimal background IEDDA reaction between tetrazine and alkene will be identified, to minimize background for the screen in the next step.<\\\/p>\\n

A Chemical Epitope Targeting screen against the Chemical Epitope, KRas(G12V) complexed to a GDPalkene small molecule, will be performed using S,S-tetrazine cyclized OBOC peptide libraries (Aim 3). Screening for inhibition of KRas (G12V)-Sos interaction using a split luciferase platform will follow. Aims 1 and 2 should be achieved, and Aim 3 be initiated within the grant period. This project, being multidisciplinary, will allow the PI to train undergraduate and graduate students at Clark University in a variety of chemical and biochemical techniques.<\\\/p>\",\"Abstract\":\"<p>Protein function modifications for therapeutic purposes are typically accomplished with small molecule drugs that bind in deep hydrophobic pockets of proteins. For protein-protein interactions occurring over an extended shallow area, it is challenging to have small molecules binding to the surface area and thereby affecting protein functions. Ras-Sos is a classic example of extensive protein-protein surface interaction, and therefore it remains challenging to inhibit KRas- Sos interactions. KRas is activated by Sos, and it is critical to develop technologies to inhibit interactions of oncogenic mutant KRas with Sos selectively. One such promising technology is the Chemical Epitope Targeting technology, developed for designing peptide ligands with high affinity and specificity against specific regions of an intracellular protein that may be inaccessible to small molecules or antibodies. This technology involves using proximity-catalyzed reaction for screening a specific region of the target protein to isolate peptide ligands.<\\\/p>\\n<p>The PI proposes to streamline this technology to make it more accessible and user-friendly, and then to tailor this technology to successfully target mutant KRas(G12V) protein, specifically at the Ras-Sos interface. The technology will be streamlined by developing and characterizing synthetic macrocyclic one-bead-one compound (OBOC) peptide libraries that can be cleaved by one-step light exposure for seamless sequencing by tandem Mass Spectrometry (MS\\\/MS) (Aim 1). Inverse Electron Demand Diels Alder (IEDDA) reaction between tetrazine and alkyne will be used for the screening process rather than the currently used azide-alkyne cycloaddition.<\\\/p>\\n<p>The PI shall demonstrate, as a proof-of-concept, that IEDDA reaction between substituted tetrazine and an alkene can be proximity-catalyzed by a protein. KRas(G12C) or KRas mutants with one Cys will be modified at Cys with tetrazine. The labeling of the complex with an alkene containing Sos-helix peptide, known to bind at the Ras- Sos interface, will be monitored using tandem Mass Spectrometry (Aim 2). The optimal temperature for minimal background IEDDA reaction between tetrazine and alkene will be identified, to minimize background for the screen in the next step.<\\\/p>\\n<p>A Chemical Epitope Targeting screen against the Chemical Epitope, KRas(G12V) complexed to a GDPalkene small molecule, will be performed using S,S-tetrazine cyclized OBOC peptide libraries (Aim 3). Screening for inhibition of KRas (G12V)-Sos interaction using a split luciferase platform will follow. Aims 1 and 2 should be achieved, and Aim 3 be initiated within the grant period. This project, being multidisciplinary, will allow the PI to train undergraduate and graduate students at Clark University in a variety of chemical and biochemical techniques.<\\\/p>\",\"Number of Periods\":4,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"6463\":{\"id\":6463,\"grantid\":334,\"fundedamount\":\"150287\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2020-09-01\",\"enddate\":\"2021-09-01\"},\"6464\":{\"id\":6464,\"grantid\":334,\"fundedamount\":\"150287\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2021-09-01\",\"enddate\":\"2022-09-01\"},\"6465\":{\"id\":6465,\"grantid\":334,\"fundedamount\":\"150287\",\"yearfunded\":3,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2022-09-01\",\"enddate\":\"2023-09-01\"},\"6466\":{\"id\":6466,\"grantid\":334,\"fundedamount\":\"0\",\"yearfunded\":4,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2023-09-01\",\"enddate\":\"2024-09-01\"},\"6467\":{\"id\":6467,\"grantid\":334,\"fundedamount\":\"99991.67\",\"yearfunded\":1,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2020-09-01\",\"enddate\":\"2021-09-01\"},\"6468\":{\"id\":6468,\"grantid\":334,\"fundedamount\":\"99991.67\",\"yearfunded\":2,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2021-09-01\",\"enddate\":\"2022-09-01\"},\"6469\":{\"id\":6469,\"grantid\":334,\"fundedamount\":\"99991.67\",\"yearfunded\":3,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2022-09-01\",\"enddate\":\"2023-09-01\"},\"6470\":{\"id\":6470,\"grantid\":334,\"fundedamount\":\"0\",\"yearfunded\":4,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2023-09-01\",\"enddate\":\"2024-09-01\"}},\"coauthors\":{\"5963\":{\"authorid\":5963,\"grantid\":334,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":334,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":3,\"completionorder\":5},{\"grantid\":334,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Fall\",\"year\":2020,\"termid\":\"2020\\\/01\",\"listingorder\":3,\"completionorder\":5}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2024-08-31\"},{\"activityid\":3701,\"fields\":{\"Title\":\"Development of Cysteine-quinone reaction aided Chemical Epitope Targeting technology for isolating peptide inhibitors of KRAS(G12C)-SOS interaction\",\"Sponsor\":\"Cottrell Scholar Award, Research Corporation for Science Advancement \",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2021-08-01\",\"End Date\":\"2024-07-30\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"100000\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"\",\"Number of Periods\":3,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"6399\":{\"id\":6399,\"grantid\":3701,\"fundedamount\":\"33000\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2021-08-01\",\"enddate\":\"2022-08-01\"},\"6400\":{\"id\":6400,\"grantid\":3701,\"fundedamount\":\"33000\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2022-08-01\",\"enddate\":\"2023-08-01\"},\"6401\":{\"id\":6401,\"grantid\":3701,\"fundedamount\":\"34000\",\"yearfunded\":3,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2023-08-01\",\"enddate\":\"2024-08-01\"}},\"coauthors\":{\"5952\":{\"authorid\":5952,\"grantid\":3701,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":3701,\"status\":\"Submitted - Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":5,\"completionorder\":3}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2024-07-30\"},{\"activityid\":336,\"fields\":{\"Title\":\"Hydrocarbon metathesis on peptide-small molecule scaffold\",\"Sponsor\":\"American Chemical Society Petroleum Research Fund\",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2020-09-01\",\"End Date\":\"2022-08-31\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"110000\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"<p>We propose to develop a modified Hoveyda-Grubbs II catalyst by incorporating ruthenium-carbene in a peptide-small molecule scaffold. Hoveyda-Grubbs II catalyst is used in the petroleum industry as a hydrocarbon metathesis catalyst for sterically<\\\/p>\\n<p>crowded hydrocarbons. Improving the catalyst efficiency involves the tedious individual synthesis of hundreds of organometallic compounds to identify one catalyst. A recently explored alternate route is artificial metalloenzyme evolution, which does not allow the incorporation of efficiency-increasing functionalities like pyridylalanine. The proposed approach harnesses the strengths of both technologies. The objective is to determine how the changes in primary and secondary coordination spheres of ruthenium in a Hoveyda-Grubbs II type catalyst affect its efficiency and selectivity. We hypothesize that incorporation of the ruthenium-carbene in heptapeptides creates sufficient variation in primary and secondary coordination spheres of the metal, such that specific peptide sequences can enhance the catalytic efficiency or selectivity. To test this hypothesis, we shall synthesize a peptide-small molecule scaffold library, guided by mutation studies of an artificial metalloenzyme to a modified Hoveyda-Grubbs II catalyst. 625 unique heptapeptides with ruthenium-carbene complex will be screened for catalytic activities, by monitoring the formation of a fluorescent product from the metathesis\\u00a0reaction of a non-fluorescent substrate. The identified candidates will be sequenced using Mass Spectrometry. The rate of catalysis of olefin metathesis for different substrates will\\u00a0be determined for each candidate. The nature of candidate catalysts will be studied to give fundamental insight into how molecular interactions can increase the selectivity and efficiency of a modified Hoveyda-Grubbs II catalyst.<\\\/p>\",\"Number of Periods\":2,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"1871\":{\"id\":1871,\"grantid\":336,\"fundedamount\":\"55000\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2020-09-01\",\"enddate\":\"2021-09-01\"},\"1872\":{\"id\":1872,\"grantid\":336,\"fundedamount\":\"55000\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2021-09-01\",\"enddate\":\"2022-09-01\"}},\"coauthors\":{\"1576\":{\"authorid\":1576,\"grantid\":336,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":336,\"status\":\"Submitted - Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Fall\",\"year\":2020,\"termid\":\"2020\\\/01\",\"listingorder\":5,\"completionorder\":3}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2022-08-31\"},{\"activityid\":333,\"fields\":{\"Title\":\"Environment-friendly mononuclear and binuclear copper-peptide complexes as water oxidation catalysts\",\"Sponsor\":\"American Association of University Women \",\"Grant ID \\\/ Contract ID\":\"Research Publication Grant in Engineering, Medicine and Science, 2020-21\",\"Award Date\":\"2020-04-15\",\"Start Date\":\"2020-07-15\",\"End Date\":\"2021-07-15\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"10249\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"

Having a strong publication record is a key to receiving promotions and tenure in engineering, medicine and science. Yet persistent gender stereotypes and bias in these fields can make it difficult for women to find the time and institutional support needed to publish their research. These grants help women overcome these barriers by funding research projects that will culminate in scholarly publications.<\\\/p>\\n

They are open to women scholars conducting basic research in engineering, medicine or the physical or biological sciences and who have a doctorate degree in one of those fields. The grantee must publish their research in a scholarly publication and be listed as a primary author.<\\\/p>\",\"Abstract\":\"<p>Water splitting is an efficient natural catalytic reaction which has a significant application in renewable energy research, for the storage of solar energy as chemical energy. Photosystem II in plants performs the water oxidation reaction using an (Mn)4Ca cluster, which is unstable outside the protein environment. To overcome the instability of the active cluster, scientists have tried to mimic the catalytic center using organic ligand complexes of higher transition metals like Ruthenium (Ru) and Platinum (Pt), which are expensive and create toxic by-products. The goal of this project is to\\u00a0develop an environment-friendly Copper (Cu) based catalyst for water oxidation by modifying the ligand framework of an existing Cu-peptide water oxidation catalyst. A hypothesis was made that modifying the ligand framework can affect the primary and secondary coordination spheres of the metal in the catalyst complex and therefore affect its catalytic properties. Our results in potentiometry experiments support this hypothesis as the incorporation of alkyl\\\/aryl, phosphoryl, and fluoro-substitutions(s) in the complex, improving the catalysis of water oxidation. The modular nature of the synthesis affords precise control in defining the catalyst environment and allows such optimization. We shall complete this study by quantifying the molecular oxygen evolution by the most efficient catalyst candidates. This study advances the development of environment-friendly small biomimetic systems as efficient water oxidation catalysts by defining some parameters of efficient design. A second hypothesis that linking two molecules of the catalytic core to make a binuclear copper complex will further improve the water oxidation catalytic activity has been validated. We have developed a binuclear copper peptide complex with superior water oxidation catalysis. This grant will allow us to publish one article focusing on mononuclear copper complex catalysis and will advance the work on a second publication about the binuclear copper catalyst significantly.<\\\/p>\",\"Number of Periods\":1,\"URL\":\"https:\\\/\\\/www.aauw.org\\\/resources\\\/programs\\\/fellowships-grants\\\/current-opportunities\\\/research-publication-grants\\\/\"},\"facultyid\":\"C70252069\",\"funding\":{\"6412\":{\"id\":6412,\"grantid\":333,\"fundedamount\":\"10249\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2020-07-15\",\"enddate\":\"2021-07-15\"}},\"coauthors\":{\"5954\":{\"authorid\":5954,\"grantid\":333,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":333,\"status\":\"Completed\",\"statuslabel\":\"Completed\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":4,\"completionorder\":6},{\"grantid\":333,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Fall\",\"year\":2020,\"termid\":\"2020\\\/01\",\"listingorder\":3,\"completionorder\":5}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2021-07-15\"},{\"activityid\":337,\"fields\":{\"Title\":\"Development of on-resin cyclic tetrazine libraries for isolating inhibitor of KRas (G12V) -Sos interaction, via proximity-catalyzed Inverse Electron Demand Diels-Alder.\",\"Sponsor\":\"Clark University\",\"Grant ID \\\/ Contract ID\":\"Faculty Development Grant\",\"Award Date\":null,\"Start Date\":\"2020-08-15\",\"End Date\":null,\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"2100\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"\",\"Number of Periods\":1,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"729\":{\"id\":729,\"grantid\":337,\"fundedamount\":\"2100\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2020-08-15\",\"enddate\":\"2021-08-15\"}},\"coauthors\":{\"484\":{\"authorid\":484,\"grantid\":337,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":337,\"status\":\"Submitted - Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Spring\",\"year\":2020,\"termid\":\"2019\\\/03\",\"listingorder\":5,\"completionorder\":3}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2020-08-15\"},{\"activityid\":3703,\"fields\":{\"Title\":\"Environment-friendly mononuclear and binuclear copper-peptide complexes as water oxidation catalysts\",\"Sponsor\":\"American Association of University Women \",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":null,\"Start Date\":\"2018-10-01\",\"End Date\":\"2019-10-01\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"30000\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"\",\"Number of Periods\":1,\"URL\":\"\"},\"facultyid\":\"C70252069\",\"funding\":{\"6433\":{\"id\":6433,\"grantid\":3703,\"fundedamount\":\"30000\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2018-10-01\",\"enddate\":\"2019-10-01\"}},\"coauthors\":{\"5957\":{\"authorid\":5957,\"grantid\":3703,\"firstname\":\"Arundhati\",\"middleinitial\":\"\",\"lastname\":\"Nag\",\"authortype\":\"PI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C70252069\",\"primaryunitid\":9}},\"status\":[{\"grantid\":3703,\"status\":\"Submitted - Not Funded\",\"statuslabel\":\"Submitted - Not Funded\",\"term\":\"Spring\",\"year\":2018,\"termid\":\"2017\\\/03\",\"listingorder\":5,\"completionorder\":3}],\"userid\":\"C70252069\",\"attachments\":[],\"sort_date\":\"2019-10-01\"}]","cu_faculty_title":"Associate Professor, Chemistry","cu_faculty_department":"Chemistry","cu_faculty_affiliated_departments":"Chemistry","footnotes":""},"cu_faculty_group":[],"cu_faculty_department":[24],"cu_faculty_position":[],"class_list":["post-921","cu_faculty","type-cu_faculty","status-publish","has-post-thumbnail","hentry","cu_faculty_department-chemistry"],"yoast_head":"\nArundhati Nag | Faculty<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Arundhati Nag\" \/>\n<meta property=\"og:description\" content=\"Professor Nag’s lab develops unique peptide or peptidomimetic macrocycles using robust chemical reactions and Solid Phase Peptide Synthesis. 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Chemical synthesis of macrocycles allows one to incorporate unique properties such as thermal and protease stability […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/\" \/>\n<meta property=\"og:site_name\" content=\"Faculty\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-05T23:09:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Arundhati-Nag-720x720-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/\",\"name\":\"Arundhati Nag | Faculty\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Arundhati-Nag-720x720-1.jpg\",\"datePublished\":\"2024-12-19T15:30:48+00:00\",\"dateModified\":\"2026-04-05T23:09:27+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/arundhati-nag\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Arundhati-Nag-720x720-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Arundhati-Nag-720x720-1.jpg\",\"width\":720,\"height\":720,\"caption\":\"Arundhati Nag\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\\\/921#breadcrumbs\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":0,\"name\":\"ClarkU\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Faculty\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\\\/921\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/#website\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/\",\"name\":\"Faculty\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Arundhati Nag | Faculty","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/","og_locale":"en_US","og_type":"article","og_title":"Arundhati Nag","og_description":"Professor Nag’s lab develops unique peptide or peptidomimetic macrocycles using robust chemical reactions and Solid Phase Peptide Synthesis. Macrocycles, with molecular weights of approximately 1000, bridge the gap between small molecules and proteins, in terms of size and composition. Chemical synthesis of macrocycles allows one to incorporate unique properties such as thermal and protease stability […]","og_url":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/","og_site_name":"Faculty","article_modified_time":"2026-04-05T23:09:27+00:00","og_image":[{"width":720,"height":720,"url":"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Arundhati-Nag-720x720-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/","url":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/","name":"Arundhati Nag | Faculty","isPartOf":{"@id":"https:\/\/www.clarku.edu\/faculty\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/#primaryimage"},"image":{"@id":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/#primaryimage"},"thumbnailUrl":"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Arundhati-Nag-720x720-1.jpg","datePublished":"2024-12-19T15:30:48+00:00","dateModified":"2026-04-05T23:09:27+00:00","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.clarku.edu\/faculty\/profiles\/arundhati-nag\/#primaryimage","url":"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Arundhati-Nag-720x720-1.jpg","contentUrl":"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Arundhati-Nag-720x720-1.jpg","width":720,"height":720,"caption":"Arundhati Nag"},{"@type":"BreadcrumbList","@id":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty\/921#breadcrumbs","itemListElement":[{"@type":"ListItem","position":0,"name":"ClarkU","item":"https:\/\/www.clarku.edu\/"},{"@type":"ListItem","position":1,"name":"Faculty","item":"https:\/\/www.clarku.edu\/faculty"},{"@type":"ListItem","position":2,"name":"Profiles","item":"https:\/\/www.clarku.edu\/faculty\/wp-json"},{"@type":"ListItem","position":3,"name":"Profiles","item":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp"},{"@type":"ListItem","position":4,"name":"Profiles","item":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2"},{"@type":"ListItem","position":5,"name":"Profiles","item":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty"},{"@type":"ListItem","position":6,"name":"Profiles","item":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty\/921"}]},{"@type":"WebSite","@id":"https:\/\/www.clarku.edu\/faculty\/#website","url":"https:\/\/www.clarku.edu\/faculty\/","name":"Faculty","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.clarku.edu\/faculty\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty\/921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty"}],"about":[{"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/types\/cu_faculty"}],"version-history":[{"count":1,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty\/921\/revisions"}],"predecessor-version":[{"id":963,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty\/921\/revisions\/963"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/media\/1936"}],"wp:attachment":[{"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/media?parent=921"}],"wp:term":[{"taxonomy":"cu_faculty_group","embeddable":true,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty_group?post=921"},{"taxonomy":"cu_faculty_department","embeddable":true,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty_department?post=921"},{"taxonomy":"cu_faculty_position","embeddable":true,"href":"https:\/\/www.clarku.edu\/faculty\/wp-json\/wp\/v2\/cu_faculty_position?post=921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}