{"id":65,"date":"2024-12-09T10:31:38","date_gmt":"2024-12-09T15:31:38","guid":{"rendered":"https:\/\/www.golive.clarku.edu\/faculty\/profiles\/denis-larochelle\/"},"modified":"2026-04-09T10:08:18","modified_gmt":"2026-04-09T14:08:18","slug":"denis-larochelle","status":"publish","type":"cu_faculty","link":"https:\/\/www.clarku.edu\/faculty\/profiles\/denis-larochelle\/","title":{"rendered":"Denis Larochelle"},"content":{"rendered":"<p><span>Cytokinesis, the process by which a cell constricts at the equator to ultimately divide into two daughter cells remains poorly understood. My primary interest has been to identify the proteins\/genes involved in both the mechanics and the regulation of this process. To achieve this goal my lab uses the cellular slime mold\u00a0<\/span><em>Dictyostelium discoideum<\/em><span>. Using\u00a0<\/span><em>Dictyostelium<\/em><span>\u00a0a molecular genetic screen was developed to identify the genes required for cytokinesis. Several genes were subsequently identified and we are in the process of describing how these genes participate in the regulation of cytokinesis. One of these genes codes for a novel small GTP-binding protein of the ras superfamily. Initial characterization of mutant cell lines containing disruptions in this gene, named\u00a0<\/span><em>racE<\/em><span>, has revealed\u00a0<\/span><em>racE<\/em><span>\u00a0to be essential solely for cytokinesis, and all other aspects of\u00a0<\/span><em>Dictyostelium<\/em><span>\u00a0biology2 appear to be normal in these cells. A second gene has recently been identified which also functions in cytokinesis. We are still in the process of characterizing this gene but limited sequence analysis reveals strong homology to the mouse\u00a0<\/span><em>beige<\/em><span>\u00a0gene and the human gene responsible for the Chediak-Higashi syndrome. We are now in the process of trying to understand the cell biology and biochemistry of how these genes function in cytokinesis. Future work will include further characterization of these genes, as well as continuation of the screen to identify additional genes involved in cytokinesis.<\/span><\/p>\n","protected":false},"author":0,"featured_media":1910,"parent":0,"template":"","meta":{"cu_faculty_f180_userid":"C10631332","cu_faculty_first_name":"Denis","cu_faculty_last_name":"Larochelle","cu_faculty_employment_status":"Full Time","cu_faculty_rank":"Associate Professor","cu_faculty_position":"Professor<br \/>Medical Careers Director","cu_faculty_phone":"","cu_faculty_email":"dlarochelle@clarku.edu","cu_faculty_location":"","cu_faculty_about":"<p><span>Cytokinesis, the process by which a cell constricts at the equator to ultimately divide into two daughter cells remains poorly understood. My primary interest has been to identify the proteins\/genes involved in both the mechanics and the regulation of this process. To achieve this goal my lab uses the cellular slime mold\u00a0<\/span><em>Dictyostelium discoideum<\/em><span>. Using\u00a0<\/span><em>Dictyostelium<\/em><span>\u00a0a molecular genetic screen was developed to identify the genes required for cytokinesis. Several genes were subsequently identified and we are in the process of describing how these genes participate in the regulation of cytokinesis. One of these genes codes for a novel small GTP-binding protein of the ras superfamily. Initial characterization of mutant cell lines containing disruptions in this gene, named\u00a0<\/span><em>racE<\/em><span>, has revealed\u00a0<\/span><em>racE<\/em><span>\u00a0to be essential solely for cytokinesis, and all other aspects of\u00a0<\/span><em>Dictyostelium<\/em><span>\u00a0biology2 appear to be normal in these cells. A second gene has recently been identified which also functions in cytokinesis. We are still in the process of characterizing this gene but limited sequence analysis reveals strong homology to the mouse\u00a0<\/span><em>beige<\/em><span>\u00a0gene and the human gene responsible for the Chediak-Higashi syndrome. We are now in the process of trying to understand the cell biology and biochemistry of how these genes function in cytokinesis. Future work will include further characterization of these genes, as well as continuation of the screen to identify additional genes involved in cytokinesis.<\/span><\/p>","cu_faculty_degrees":"<span>Ph.D. in Biological Sciences,<\/span> Stanford University, 1991\n<span>M.S. in Zoology,<\/span> University of New Hampshire, 1985\n<span>B.A. in Zoology,<\/span> University of New Hampshire, 1983","cu_faculty_cv":"https:\/\/faculty180.interfolio.com\/public\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zME1HQTdlRTVLTExCMXVMWjM3emZYWTFCbzlWWHdqNXFNQUpHVDhCZDE4V3F5d0JpZWNFdStpQkxpUzJMUFZWQT09","cu_faculty_links":"[]","cu_faculty_scholarly_interests":"","cu_faculty_scholarly_works":"[{\"activityid\":7673,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"&lt;strong&gt;The\\u00a0&lt;span style=&quot;font-style:italic;&quot;&gt;Dictyostelium discoideum&lt;\\\/span&gt;\\u00a0genome lacks significant DNA methylation and uncovers palindromic sequences as a source of false positives in bisulfite sequencing&lt;\\\/strong&gt;\",\"Journal Title\":\"NAR Genomics and Bioinformatics\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2023,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C10631332\",\"status\":[{\"id\":7673,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2023,\"termid\":\"2022\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C10631332\",\"attachments\":[],\"coauthors_list\":[\"Robert Drewell\",\"Tayla C Cormier\",\"Jacob L Steenwyk\",\"James St. Denis\",\"Javier F Tabima Restrepo\",\"Jacqueline M. Dresch\",\"Denis A Larochelle\"],\"sort_date\":\"2023-1-01\"},{\"activityid\":742,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Determining the effects of methylation by DnmA in Dictyostelium discoideum.  \",\"Conference \\\/ Meeting Name\":\"Northeast Nuclear Envelope Meeting\",\"Location of Conference \\\/ Meeting\":\"Yale University, New Haven CT\",\"Month \\\/ Season\":\"September\",\"Year\":2019,\"Sponsoring Organization\":\"American Society For Cell Biology\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C10631332\",\"status\":[{\"id\":742,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2019,\"termid\":\"2019\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C10631332\",\"attachments\":[],\"coauthors_list\":[\"Zaza Gelashvili\",\"Denis A Larochelle\"],\"sort_date\":\"2019-9-01\"},{\"activityid\":743,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"The Dictyostelium Nuclear Envelope. \",\"Conference \\\/ Meeting Name\":\"Northeast Nuclear Envelope Meeting\",\"Location of Conference \\\/ Meeting\":\"Yale University, New Haven CT\",\"Month \\\/ Season\":\"September\",\"Year\":2019,\"Sponsoring Organization\":\"American Society for Cell Biology\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C10631332\",\"status\":[{\"id\":743,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2019,\"termid\":\"2019\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C10631332\",\"attachments\":[],\"coauthors_list\":[\"Denis A Larochelle\"],\"sort_date\":\"2019-9-01\"},{\"activityid\":889,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Nuclear envelope organization in Dictyostelium discoideum\",\"Journal Title\":\"International Journal of Developmental Biology\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2019,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"63\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"509-519\",\"ISSN\":\"Online: 1696-3547; Print: 0214-6282\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C10631332\",\"status\":[{\"id\":889,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2019,\"termid\":\"2018\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C10631332\",\"attachments\":[{\"attachmentid\":483,\"mimetype\":\"application\\\/pdf\",\"filename\":\"full paper2019 dicty NE.pdf\",\"filesize\":3732295,\"downloadurl\":\"https:\\\/\\\/faculty180.interfolio.com\\\/public\\\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zME1HQTdlRTVLTG9KNTRrcjk0dmVObzNLbExVTEVLVWVNa1I3Zk9aYURzYUEzZmRkRk5BUmliQTFLVHg3aFBseU5qSFB5MTZPS3Y%3D\"}],\"coauthors_list\":[\"Petros Batsios\",\"Ralph Graf\",\"Michael P Koonce\",\"Denis A Larochelle\",\"Irene Meyer\"],\"sort_date\":\"2019-1-01\"},{\"activityid\":3658,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Whole genome bisulfite sequencing reveals a sparse, but robust pattern of DNA methylation in the Dictyostelium discoideum genome\",\"Journal Title\":\"BIORXIV\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2017,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C10631332\",\"status\":[{\"id\":3658,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2017,\"termid\":\"2016\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C10631332\",\"attachments\":[],\"coauthors_list\":[\"Jacob Steenwyk\",\"James St. Denis\",\"Jacqueline M. Dresch\",\"Denis A Larochelle\",\"Robert Drewell\"],\"sort_date\":\"2017-1-01\"}]","cu_faculty_awards_and_grants":"[{\"activityid\":4806,\"fields\":{\"Title\":\"Investigating the function of the DNMT2-homolog (DNMA) in Dictyostelium discoideum\",\"Sponsor\":\"NSF\",\"Grant ID \\\/ Contract ID\":\"253278\",\"Award Date\":null,\"Start Date\":\"2026-01-01\",\"End Date\":null,\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":1,\"Indirect Cost Rate\":\"50.3\",\"Total Funding\":\"0\",\"Total Direct Funding\":\"0\",\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"&lt;p&gt;In this proposed study, we will fully explore the function of the DNMT2 homolog (DNMA) in &lt;em&gt;Dictyostelium discoideum&lt;\\\/em&gt; by examining the biological activity of the enzyme in three independent parallel goals.\\u00a0 &lt;strong&gt;In the first goal, the phenotypic effects resulting from deletion of this enzyme will be characterized.&lt;\\\/strong&gt;\\u00a0 Our preliminary data and prior studies indicate that pleiotropic impacts on cell growth, morphology and motility, nuclear organization, and disruption to the developmental program will be detected.\\u00a0 &lt;strong&gt;In the second goal, we will investigate the impact of loss of DNMA on translation efficiency in a transgenic reporter system.&lt;\\\/strong&gt;\\u00a0 Specifically, we will analyze translation of mRNAs encoding fluorescent fusion proteins containing different codon targets of the tRNA&lt;sup&gt;Asp&lt;\\\/sup&gt;&lt;sub&gt;GUC&lt;\\\/sub&gt; anticodon.\\u00a0 &lt;strong&gt;In the third goal, we will analyze global gene expression in the &lt;em&gt;dnmA &lt;\\\/em&gt;knock-out cells and compare the transcriptome profile to wild-type cells.&lt;\\\/strong&gt; \\u00a0Our experiments will comprehensively investigate the biological role of DNMA, as a tRNA methyltransferase, and address the activity of this enzyme in normal cellular activity and development in &lt;em&gt;Dictyostelium&lt;\\\/em&gt;.&lt;\\\/p&gt;\",\"Number of Periods\":3,\"URL\":\"\"},\"facultyid\":\"C10631332\",\"funding\":{\"8098\":{\"id\":8098,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2026-01-01\",\"enddate\":\"2027-01-01\"},\"8099\":{\"id\":8099,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":2,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2027-01-01\",\"enddate\":\"2028-01-01\"},\"8100\":{\"id\":8100,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":3,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2028-01-01\",\"enddate\":\"2029-01-01\"},\"8101\":{\"id\":8101,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":1,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2026-01-01\",\"enddate\":\"2027-01-01\"},\"8102\":{\"id\":8102,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":2,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2027-01-01\",\"enddate\":\"2028-01-01\"},\"8103\":{\"id\":8103,\"grantid\":4806,\"fundedamount\":\"0\",\"yearfunded\":3,\"fundedtype\":\"Direct\",\"currencytype\":\"USD\",\"startdate\":\"2028-01-01\",\"enddate\":\"2029-01-01\"}},\"coauthors\":{\"7550\":{\"authorid\":7550,\"grantid\":4806,\"firstname\":\"Robert\",\"middleinitial\":\"A\",\"lastname\":\"Drewell\",\"authortype\":\"CoPI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C10631332\",\"primaryunitid\":7}},\"status\":[{\"grantid\":4806,\"status\":\"Submitted for Review\",\"statuslabel\":\"Submitted for Review\",\"term\":\"Spring\",\"year\":2026,\"termid\":\"2025\\\/03\",\"listingorder\":2,\"completionorder\":2}],\"userid\":\"C10631332\",\"attachments\":[{\"attachmentid\":11446,\"mimetype\":\"application\\\/pdf\",\"filename\":\"NSF DNMA Project Description Apr 25.pdf\",\"filesize\":871408,\"downloadurl\":\"https:\\\/\\\/faculty180.interfolio.com\\\/public\\\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zME1HQTdlRTVLTExCMXVMWjM3emZWcHhYUzVSNDlNM2hhZDVaTCt0QmE5aFdONjlwRHBTRzhmdUVraUl1TE9lcnpmb0pDUklHdFFpaDRueTFJdW5oU2lCTGlTMkxQVlZBPT0%3D\"}],\"sort_date\":\"2026-01-01\"},{\"activityid\":1771,\"fields\":{\"Title\":\"Investigating epigenetic nucleic acid methylation in Dictyostelium slime mold\",\"Sponsor\":\"Faculty Development Grant, Clark University\",\"Grant ID \\\/ Contract ID\":\"\",\"Award Date\":\"2022-03-02\",\"Start Date\":\"2022-06-01\",\"End Date\":\"2023-05-31\",\"Period Length\":1,\"Period Unit\":\"Year\",\"Indirect Funding\":0,\"Indirect Cost Rate\":null,\"Total Funding\":\"10000\",\"Total Direct Funding\":null,\"Currency Type\":\"USD\",\"Description\":\"\",\"Abstract\":\"&lt;p&gt;&lt;span&gt;As faculty members in the Biology department working at the interface of Molecular Genetics, Cell Biology and Genomics it is crucial to our research programs to build a successful collaboration that includes undergraduate and&lt;br&gt;graduate students from the Biology and Biochemistry and Molecular Biology (BCMB) programs. STEM is a key area with a deep need for efforts focused on Diversity, Equity and Inclusion, so we will aggressively advertise these research&lt;br&gt;opportunities to all students in order to increase representation and mentoring of students traditionally underrepresented in the sciences. Below we outline a research project that will synergistically incorporate novel approaches from multiple disciplines to build upon the existing collaboration between our three groups to unravel the functional and evolutionary role of methylation of DNA and RNA molecules in the slime mold, &lt;\\\/span&gt;&lt;span&gt;Dictyostelium discoideum&lt;\\\/span&gt;&lt;span&gt;. The successful completion of this pilot project will lay the foundation for larger-scale\\u00a0 collaborative grant proposals to the NSF and\\\/or NIH.&lt;\\\/span&gt; &lt;\\\/p&gt;\",\"Number of Periods\":1,\"URL\":\"\"},\"facultyid\":\"C10631332\",\"funding\":{\"2968\":{\"id\":2968,\"grantid\":1771,\"fundedamount\":\"10000\",\"yearfunded\":1,\"fundedtype\":\"Total\",\"currencytype\":\"USD\",\"startdate\":\"2022-06-01\",\"enddate\":\"2023-06-01\"}},\"coauthors\":{\"2586\":{\"authorid\":2586,\"grantid\":1771,\"firstname\":\"Denis\",\"middleinitial\":\"A\",\"lastname\":\"Larochelle\",\"authortype\":\"CoPI\",\"percenteffort\":null,\"sameschoolflag\":1,\"facultyid\":\"C10631332\",\"primaryunitid\":7}},\"status\":[{\"grantid\":1771,\"status\":\"Funded - In Progress\",\"statuslabel\":\"Funded - In Progress\",\"term\":\"Fall\",\"year\":2022,\"termid\":\"2022\\\/01\",\"listingorder\":3,\"completionorder\":5}],\"userid\":\"C10631332\",\"attachments\":[{\"attachmentid\":4124,\"mimetype\":\"application\\\/pdf\",\"filename\":\"Drewell_Larochelle_Tabima_FD22.pdf\",\"filesize\":1613055,\"downloadurl\":\"https:\\\/\\\/faculty180.interfolio.com\\\/public\\\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zME1HQTdlRTVLTCtSOFM0R0ZTaTl2MTVQUk5WbDJ0c1p1Yjd1K0hoRUlMcGR3enBRMmtCaHUveVdIVzlTOTJuWjZMeTdJK0pKcFdJMk1jL0xYbzRxOD0%3D\"}],\"sort_date\":\"2023-05-31\"}]","cu_faculty_title":"Professor, Biology<br \/>Medical Careers Director, Biology","cu_faculty_department":"Biology","cu_faculty_affiliated_departments":"Biology","footnotes":""},"cu_faculty_group":[],"cu_faculty_department":[15],"cu_faculty_position":[],"class_list":["post-65","cu_faculty","type-cu_faculty","status-publish","has-post-thumbnail","hentry","cu_faculty_department-biology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Denis Larochelle | Faculty<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.clarku.edu\/faculty\/profiles\/denis-larochelle\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Denis Larochelle\" \/>\n<meta property=\"og:description\" content=\"Cytokinesis, the process by which a cell constricts at the equator to ultimately divide into two daughter cells remains poorly understood. My primary interest has been to identify the proteins\/genes involved in both the mechanics and the regulation of this process. To achieve this goal my lab uses the cellular slime mold\u00a0Dictyostelium discoideum. Using\u00a0Dictyostelium\u00a0a molecular [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.clarku.edu\/faculty\/profiles\/denis-larochelle\/\" \/>\n<meta property=\"og:site_name\" content=\"Faculty\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-09T14:08:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.clarku.edu\/faculty\/wp-content\/uploads\/sites\/5\/2024\/12\/Denis-Larochelle-720x720-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/\",\"name\":\"Denis Larochelle | Faculty\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Denis-Larochelle-720x720-1.jpg\",\"datePublished\":\"2024-12-09T15:31:38+00:00\",\"dateModified\":\"2026-04-09T14:08:18+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/profiles\\\/denis-larochelle\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Denis-Larochelle-720x720-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2024\\\/12\\\/Denis-Larochelle-720x720-1.jpg\",\"width\":720,\"height\":720,\"caption\":\"Denis Larochelle\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\\\/65#breadcrumbs\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":0,\"name\":\"ClarkU\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Faculty\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Profiles\",\"item\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/wp-json\\\/wp\\\/v2\\\/cu_faculty\\\/65\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/#website\",\"url\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/\",\"name\":\"Faculty\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.clarku.edu\\\/faculty\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Denis Larochelle | Faculty","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.clarku.edu\/faculty\/profiles\/denis-larochelle\/","og_locale":"en_US","og_type":"article","og_title":"Denis Larochelle","og_description":"Cytokinesis, the process by which a cell constricts at the equator to ultimately divide into two daughter cells remains poorly understood. 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