N\u00e9va Meyer is an associate professor in the Biology Department at Clark University in Worcester, Massachusetts, USA. Her research addresses questions of annelid and spiralian development with the goal of gaining a better understanding of how animal body plans evolved and diversified, particularly nervous systems, which are animal innovations. Currently, it is not known if a centralized nervous system (brain and nerve cord) evolved once, early during animal evolution, or if centralized nervous systems evolved multiple times. Her current research addresses this broad question by examining cellular and molecular mechanisms underlying central nervous system development in a phylogenetically important and understudied group of animals, the annelids, using techniques such as fate mapping, blastomere isolation, imaging, gene and signaling pathway manipulation and RNAseq.<\/p>\n
Dr. Meyer earned a B.S. with honors in Molecular Biology from Purdue University and a Ph.D. from the University of Washington. For her Ph.D, she worked in Dr. Henk Roelink\u2019s lab on understanding how different types of neurons are patterned along the dorsal-ventral axis of the spinal cord in chick and mouse, which was funded by an HHMI predoctoral fellowship. She also was involved in the Science Education Partnership, which integrates science into the community through outreach activities. As a result of her graduate studies, Dr. Meyer became interested in the broader question of how nervous systems evolved. She began to address this question as a postdoctoral researcher in Dr. Elaine Seaver’s lab at Kewalo Marine Lab, University of Hawaii and is continuing this research at Clark University. She is also actively engaged in making science more inclusive and supportive for everyone through a variety of activities.<\/p>\n
Courses offered:<\/p>\n
BIOL 102 Intro Biology (theme: opioid epidemic) Ph.D. in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA, 2005 N\u00e9va Meyer is an associate professor in the Biology Department at Clark University in Worcester, Massachusetts, USA. Her research addresses questions of annelid and spiralian development with the goal of gaining a better understanding of how animal body plans evolved and diversified, particularly nervous systems, which are animal innovations. Currently, it is not known if a centralized nervous system (brain and nerve cord) evolved once, early during animal evolution, or if centralized nervous systems evolved multiple times. Her current research addresses this broad question by examining cellular and molecular mechanisms underlying central nervous system development in a phylogenetically important and understudied group of animals, the annelids, using techniques such as fate mapping, blastomere isolation, imaging, gene and signaling pathway manipulation and RNAseq. BIOL 102 Intro Biology (theme: opioid epidemic) Ph.D. in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA, 2005
BIOL 143 Neuroscience
BIOL 221\/321 Developmental Biology with lab
BIOL 239\/339 Evo Devo
BIOL 240\/340 Comparative and Human Physiology with lab
<\/span>Degrees:<\/p>\n
B.S. in Molecular Biology, Purdue University, W. Lafayette, IN, USA, 1998<\/p>\n","protected":false},"author":0,"featured_media":1917,"parent":0,"template":"","meta":{"cu_faculty_f180_userid":"C70204584","cu_faculty_first_name":"N\u00e9va","cu_faculty_last_name":"Meyer","cu_faculty_employment_status":"Full Time","cu_faculty_rank":"Professor","cu_faculty_position":"Professor","cu_faculty_phone":"","cu_faculty_email":"NMeyer@clarku.edu","cu_faculty_location":"","cu_faculty_about":"
Dr. Meyer earned a B.S. with honors in Molecular Biology from Purdue University and a Ph.D. from the University of Washington. For her Ph.D, she worked in Dr. Henk Roelink\u2019s lab on understanding how different types of neurons are patterned along the dorsal-ventral axis of the spinal cord in chick and mouse, which was funded by an HHMI predoctoral fellowship. She also was involved in the Science Education Partnership, which integrates science into the community through outreach activities. As a result of her graduate studies, Dr. Meyer became interested in the broader question of how nervous systems evolved. She began to address this question as a postdoctoral researcher in Dr. Elaine Seaver's lab at Kewalo Marine Lab, University of Hawaii and is continuing this research at Clark University. She is also actively engaged in making science more inclusive and supportive for everyone through a variety of activities.
Courses offered:<\/p>\n
BIOL 143 Neuroscience
BIOL 221\/321 Developmental Biology with lab
BIOL 239\/339 Evo Devo
BIOL 240\/340 Comparative and Human Physiology with lab
<\/span>Degrees:<\/p>\n
B.S. in Molecular Biology, Purdue University, W. Lafayette, IN, USA, 1998<\/p>","cu_faculty_degrees":"Ph.D. in Molecular & Cellular Biology,<\/span> University of Washington, 2005\nB.S. in Molecular Biology, minor in Spanish,<\/span> Purdue University, 1998","cu_faculty_cv":"https:\/\/faculty180.interfolio.com\/public\/download.php?key=SDRwNCtxSUpsamxBQ213WS9ucHFuNnMwT0hzQU11b2RPQkJ2cWc3amxyUmNRdVVXTkF4MU1zT21qREtJZEdWZ2RLZGx3YUQveExwNVpVa0NVWDBCclNmQVQ2WVlJNHlXeis4b2lydm5qRFl0SW03bTJ1Z3R2MWVESUFQb3owd05ZRjEzKzk4Wjhtcz0%3D","cu_faculty_links":"{\"Professional Website URL\":\"https:\\\/\\\/wordpress.clarku.edu\\\/nmeyer\\\/\",\"ORCID ID\":\"https:\\\/\\\/orcid.org\\\/0000-0002-2002-3280\"}","cu_faculty_scholarly_interests":"","cu_faculty_scholarly_works":"[{\"activityid\":13301,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Exploration of a Putative Neurosecretory Brain Center in the Marine Annelid <em>Capitella teleta\\u00a0<\\\/em>\",\"Conference \\\/ Meeting Name\":\"Northeast Regional Society for Developmental Biology\",\"Location of Conference \\\/ Meeting\":\"Marine Biological Laboratories, Woods Hole, MA\",\"Month \\\/ Season\":\"April\",\"Year\":2025,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13301,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Matt O'Connell-Vale\",\"N\\u00e9va Meyer\"],\"sort_date\":\"2025-4-01\"},{\"activityid\":13300,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Exploration of a Neurosecretory Brain Center and its Functions in the Annelid <em>Capitella teleta<\\\/em>\",\"Conference \\\/ Meeting Name\":\"Society for Integrative and Comparative Biology\",\"Location of Conference \\\/ Meeting\":\"Atlanta, GA\",\"Month \\\/ Season\":\"January\",\"Year\":2025,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13300,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Matt O'Connell-Vale\",\"N\\u00e9va Meyer\"],\"sort_date\":\"2025-1-01\"},{\"activityid\":13303,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Molecular mechanisms underlying nerve cord formation of the segmented worm <em>Capitella teleta<\\\/em>\",\"Conference \\\/ Meeting Name\":\"Annual Meeting for the Society of Integrative and Comparative Biology\",\"Location of Conference \\\/ Meeting\":\"Atlanta, GA\",\"Month \\\/ Season\":\"January\",\"Year\":2025,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13303,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Johnny Davila-Sandoval\",\"N\\u00e9va Meyer\"],\"sort_date\":\"2025-1-01\"},{\"activityid\":13377,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"<p>In the Spotlight-Established Researcher<\\\/p>\",\"Journal Title\":\" J Exp Zool B Mol Dev Evol\",\"Series Title\":\"\",\"Month \\\/ Season\":\"January\",\"Year\":2025,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"344\",\"Issue Number \\\/ Edition\":\"1\",\"Page Number(s) or Number of Pages\":\"5-6\",\"ISSN\":\"\",\"DOI\":\"10.1002\\\/jez.b.23281\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13377,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"N\\u00e9va Meyer\"],\"sort_date\":\"2025-1-01\"},{\"activityid\":13252,\"fields\":{\"Type\":\"Chapters in Books\",\"Chapter Title\":\"Science Is Objective, Isn\\u2019t It? Countering the Effects of Structural Racism in Citation Practices\",\"Book Title\":\"Towards a Community of Antiracist Praxis in Higher Education Transformative Principles, Practices, and Resources for the Classroom\",\"Series Title\":\"\",\"Year\":2025,\"Date Published\":\"\",\"Publisher\":\"Routledge\",\"Publisher City and State\":\"\",\"Country of Publisher\":\"\",\"Edition\":\"\",\"Page Numbers\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13252,\"status\":\"In Press\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":5,\"completionorder\":5}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"N\\u00e9va Meyer\",\"Jie Y Park\",\"Laurie B. Ross\"],\"sort_date\":\"2025-01-01\"},{\"activityid\":13253,\"fields\":{\"Type\":\"Chapters in Books\",\"Chapter Title\":\"Sustaining Antiracism Beyond the Praxis Group: A Case in Biology\",\"Book Title\":\"Towards a Community of Antiracist Praxis in Higher Education Transformative Principles, Practices, and Resources for the Classroom\",\"Series Title\":\"\",\"Year\":2025,\"Date Published\":\"\",\"Publisher\":\"Routledge\",\"Publisher City and State\":\"\",\"Country of Publisher\":\"\",\"Edition\":\"\",\"Page Numbers\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13253,\"status\":\"In Press\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":5,\"completionorder\":5}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Elizabeth Bone\",\"N\\u00e9va Meyer\",\"Jie Y Park\",\"Hayley Haywood\",\"Jie Y Park\",\"Laurie B. Ross\"],\"sort_date\":\"2025-01-01\"},{\"activityid\":13302,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Role of cWnt in the specification of the ventral nerve cord in <em>Capitella teleta<\\\/em>\",\"Conference \\\/ Meeting Name\":\"83rd Meeting for the Society of Developmental Biology\",\"Location of Conference \\\/ Meeting\":\"Atlanta, GA\",\"Month \\\/ Season\":\"July\",\"Year\":2024,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13302,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2024,\"termid\":\"2023\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Johnny Davila-Sandoval\",\"N\\u00e9va Meyer\"],\"sort_date\":\"2024-7-01\"},{\"activityid\":13299,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"<span style="font-size:10pt;">Role of Wnt\\\/Beta-Catenin signaling during neurogenesis in the bilaterian annelid Capitella teleta<\\\/span>\",\"Conference \\\/ Meeting Name\":\"Annual Biomedical Research Conference for Minoritized Scientists\",\"Location of Conference \\\/ Meeting\":\"Pittsburgh, PA \",\"Month \\\/ Season\":\"November\",\"Year\":2024,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":13299,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2024,\"termid\":\"2024\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Krishna Gajjar\",\"N\\u00e9va Meyer\"],\"sort_date\":\"2024-11-01\"},{\"activityid\":10896,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Population-level immunologic variation in wild threespine stickleback (Gasterosteus aculeatus)\",\"Journal Title\":\"Fish & shellfish immunology\",\"Series Title\":null,\"Month \\\/ Season\":null,\"Year\":2024,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"109580\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":\"Wild organisms are regularly exposed to a wide range of parasites, requiring the management of an effective immune response while avoiding immunopathology. Currently, our knowledge of immunoparasitology primarily derives from controlled laboratory studies, neglecting the genetic and environmental diversity that contribute to immune phenotypes observed in wild populations. To gain insight into the immunologic variability in natural settings, we examined differences in immune gene expression of two Alaskan stickleback (Gasterosteus aculeatus) populations with varying susceptibility to infection by the cestode Schistocephalus solidus. Between these two populations, we found distinct immune gene expression patterns at the population level in response to infection with fish with fish from the high-infection population displaying signs of parasite-driven immune manipulation. Further, we found significant differences in baseline immune gene profiles between the populations, with uninfected low-infection population fish showing signatures of inflammation compared to uninfected high-infection population fish. These results shed light on divergent responses of wild populations to the same parasite, providing valuable insights into host-parasite interactions in natural ecosystems.\",\"Include description in output citation\":0,\"Origin\":\"PubMed\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":10896,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Anika M Wohlleben\",\"Javier F Tabima\",\"N\\u00e9va P Meyer\",\"Natalie C Steinel\"],\"sort_date\":\"2024-1-01\"},{\"activityid\":10897,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Capitella teleta\\u00a0gets left out: possible evolutionary shift causes loss of left tissues rather than increased neural tissue from\\u00a0dominant-negative BMPR1\",\"Journal Title\":\"Neural development\",\"Series Title\":null,\"Month \\\/ Season\":null,\"Year\":2024,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"19\",\"Issue Number \\\/ Edition\":\"1\",\"Page Number(s) or Number of Pages\":\"4\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":\"The evolution of central nervous systems (CNSs) is a fascinating and complex topic; further work is needed to understand the genetic and developmental homology between organisms with a CNS. Research into a limited number of species suggests that CNSs may be homologous across Bilateria. This hypothesis is based in part on similar functions of BMP signaling in establishing fates along the dorsal-ventral (D-V) axis, including limiting neural specification to one ectodermal region. From an evolutionary-developmental perspective, the best way to understand a system is to explore it in a wide range of organisms to create a full picture.\",\"Include description in output citation\":0,\"Origin\":\"PubMed\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":10897,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Nicole B Webster\",\"N\\u00e9va P Meyer\"],\"sort_date\":\"2024-1-01\"},{\"activityid\":5854,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"The timing and development of infections in a fish-cestode host-parasite system \",\"Journal Title\":\"Parasitology\",\"Series Title\":\"\",\"Month \\\/ Season\":\"May\",\"Year\":2022,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":5854,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2022,\"termid\":\"2021\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Anika M Wohlleben\",\"Natalie C Steinel\",\"Neva P Meyer\",\"John A. Baker\",\"Susan A. Foster\"],\"sort_date\":\"2022-5-01\"},{\"activityid\":4542,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Nature or nurture: autonomous or conditional specification of the nervous system of annelids\",\"Conference \\\/ Meeting Name\":\"80th Annual Society for Developmental Biology meeting\",\"Location of Conference \\\/ Meeting\":\"Virtual\",\"Month \\\/ Season\":\"July\",\"Year\":2021,\"Sponsoring Organization\":\"Society for Developmental Biology \",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":4542,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2021,\"termid\":\"2020\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Nicole Webster\",\"Neva Meyer\"],\"sort_date\":\"2021-7-01\"},{\"activityid\":4391,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Role of BMP signaling during early development of the annelid Capitella teleta\",\"Journal Title\":\"Developmental Biology\",\"Series Title\":\"\",\"Month \\\/ Season\":\"October\",\"Year\":2021,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"10.1016\\\/j.ydbio.2021.06.011\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"The mechanisms regulating nervous system development are still unknown for a wide variety of taxa. In insects and vertebrates, bone morphogenetic protein (BMP) signaling plays a key role in establishing the dorsal-ventral (D-V) axis and limiting the neuroectoderm to one side of that axis, leading to speculation about the conserved evolution of centralized nervous systems. Studies outside of insects and vertebrates show a more diverse picture of what, if any role, BMP signaling plays in neural development across Bilateria. This is especially true in the morphologically diverse Spiralia (\\u2248Lophotrochozoa). Despite several studies of D-V axis formation and neural induction in spiralians, there is no consensus for how these two processes are related, or whether BMP signaling may have played an ancestral role in either process. To determine the function of BMP signaling during early development of the spiralian annelid Capitella teleta, we incubated embryos and larvae in BMP4 protein for different amounts of time. Adding exogenous BMP protein to early-cleaving C. teleta embryos had a striking effect on formation of the brain, eyes, foregut, and ventral midline in a time-dependent manner. However, adding BMP did not block brain or VNC formation or majorly disrupt the D-V axis. We identified three key time windows of BMP activity. 1) BMP treatment around birth of the 3rd-quartet micromeres caused the loss of the eyes, radialization of the brain, and a reduction of the foregut, which we interpret as a loss of A- and C-quadrant identities with a possible trans-fate switch to a D-quadrant identity. 2) Treatment after the birth of micromere 4d induced formation of a third ectopic brain lobe, eye, and foregut lobe, which we interpret as a trans-fate switch of B-quadrant micromeres to a C-quadrant identity. 3) Continuous BMP treatment from late cleavage (4d \\u200b+ \\u200b12 \\u200bh) through mid-larval stages resulted in a modest expansion of Ct-chrdl expression in the dorsal ectoderm and a concomitant loss of the ventral midline (neurotroch ciliary band). Loss of the ventral midline was accompanied by a collapse of the bilaterally-symmetric ventral nerve cord, although the total amount of neural tissue was not greatly affected. Our results compared with those from other annelids and molluscs suggest that BMP signaling was not ancestrally involved in delimiting neural tissue to one region of the D-V axis. However, the effects of ectopic BMP on quadrant-identity during cleavage stages may represent a non-axial organizing signal that was present in the last common ancestor of annelids and mollusks. Furthermore, in the last common ancestor of annelids, BMP signaling may have functioned in patterning ectodermal fates along the D-V axis in the trunk. Ultimately, studies on a wider range of spiralian taxa are needed to determine the role of BMP signaling during neural induction and neural patterning in the last common ancestor of this group. Ultimately, these comparisons will give us insight into the evolutionary origins of centralized nervous systems and body plans. \",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":4391,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2021,\"termid\":\"2021\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Nicole Webster\",\"Michele Corbet\",\"Abhinav Sur\",\"Neva Meyer\"],\"sort_date\":\"2021-10-01\"},{\"activityid\":1481,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Resolving transcriptional states and predicting lineages in the annelid Capitella teleta using single-cell RNAseq\",\"Journal Title\":\"Frontiers in Ecology and Evolution\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2021,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"Evolution and diversification of cell types has contributed to animal evolution. However, gene regulatory mechanisms underlying cell fate acquisition during development remains largely uncharacterized in spiralians. Here we use a whole-organism, single-cell transcriptomic approach to map larval cell types in the annelid Capitella teleta at 24- and 48-h post gastrulation (stages 4 and 5). We identified eight unique cell clusters (undifferentiated precursors, ectoderm, muscle, ciliary-band, gut, neurons, neurosecretory cells, and protonephridia), thus helping to identify uncharacterized molecular signatures such as previously unknown neurosecretory cell markers in C. teleta. Analysis of coregulatory programs in individual clusters revealed gene interactions that can be used for comparisons of cell types across taxa. We examined the neural and neurosecretory clusters more deeply and characterized a differentiation trajectory starting from dividing precursors to neurons using Monocle3 and velocyto. Pseudotime analysis along this trajectory identified temporally-distinct cell states undergoing progressive gene expression changes over time. Our data revealed two potentially distinct neural differentiation trajectories including an early trajectory for brain neurosecretory cells. This work provides a valuable resource for future functional investigations to better understanding neurogenesis and the transitions from neural precursors to neurons in an annelid.\",\"Include description in output citation\":1,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":1481,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2021,\"termid\":\"2020\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Abhinav Sur\",\"Neva P Meyer\"],\"sort_date\":\"2021-1-01\"},{\"activityid\":4393,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"Nature or nurture: autonomous or conditional specification of the nervous system in spiralians\",\"Conference \\\/ Meeting Name\":\"Society for Integrative and Comparative Biology Annual Meeting\",\"Location of Conference \\\/ Meeting\":\"Virtual\",\"Month \\\/ Season\":\"\",\"Year\":2021,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":4393,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2021,\"termid\":\"2020\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Nicole Webster\",\"Neva Meyer\"],\"sort_date\":\"2021-1-01\"},{\"activityid\":4394,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"One cell at a time: ventral nerve cord specification in Capitella teleta during early development\",\"Conference \\\/ Meeting Name\":\"80th Annual Society for Developmental Biology meeting\",\"Location of Conference \\\/ Meeting\":\"Virtual\",\"Month \\\/ Season\":\"\",\"Year\":2021,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":4394,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2021,\"termid\":\"2020\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Johnny Davila-Sandoval\",\"Allan Carrillo-Baltodano\",\"Neva Meyer\"],\"sort_date\":\"2021-1-01\"},{\"activityid\":4392,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"The role of BMP signaling in early development of the spiralian Capitella teleta\",\"Conference \\\/ Meeting Name\":\"79th Annual Society for Developmental Biology meeting\",\"Location of Conference \\\/ Meeting\":\"Virtual\",\"Month \\\/ Season\":\"\",\"Year\":2020,\"Sponsoring Organization\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":4392,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2020,\"termid\":\"2019\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Nicole Webster\",\"Neva Meyer\"],\"sort_date\":\"2020-1-01\"},{\"activityid\":8365,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Investigating cellular and molecular mechanisms of neurogenesis in the annelid <em>Capitella teleta<\\\/em> shed light on the ancestor of Annelida.\",\"Journal Title\":\"BMC Evolutionary Biology\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2020,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"20\",\"Issue Number \\\/ Edition\":\"\",\"Page Number(s) or Number of Pages\":\"84\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":8365,\"status\":\"Completed\\\/Published\",\"term\":\"Summer\",\"year\":2020,\"termid\":\"2019\\\/05\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"A Sur\",\"A Renfro\",\"P J Bergmann\",\"N P Meyer\"],\"sort_date\":\"2020-1-01\"},{\"activityid\":1574,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Developmental architecture of the nervous system in Themiste lageniformis (Sipuncula): New evidence from confocal laser scanning microscopy and gene expression\",\"Journal Title\":\"Journal of morphology\",\"Series Title\":null,\"Month \\\/ Season\":null,\"Year\":2019,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"280\",\"Issue Number \\\/ Edition\":\"11\",\"Page Number(s) or Number of Pages\":\"1628-1650\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":\"Sipuncula is a clade of unsegmented marine worms that are currently placed among the basal radiation of conspicuously segmented Annelida. Their new location provides a unique opportunity to reinvestigate the evolution and development of segmented body plans. Neural segmentation is clearly evident during ganglionic ventral nerve cord (VNC) formation across Sedentaria and Errantia, which includes the majority of annelids. However, recent studies show that some annelid taxa outside of Sedentaria and Errantia have a medullary cord, without ganglia, as adults. Importantly, neural development in these taxa is understudied and interpretation can vary widely. For example, reports in sipunculans range from no evidence of segmentation to vestigial segmentation as inferred from a few pairs of serially repeated neuronal cell bodies along the VNC. We investigated patterns of pan-neuronal, neuronal subtype, and axonal markers using immunohistochemistry and whole mount in situ hybridization (WMISH) during neural development in an indirect-developing sipunculan, Themiste lageniformis. Confocal imaging revealed two clusters of 5HT neurons, two pairs of FMRF neurons, and Tubulin peripheral neurites that appear to be serially positioned along the VNC, similar to other sipunculans, to other annelids, and to spiralian taxa outside of Annelida. WMISH of a synaptotagmin1 ortholog in T. lageniformis (Tl-syt1) showed expression throughout the centralized nervous system (CNS), including the VNC where it appears to correlate with mature 5HT and FMRF neurons. An ortholog of elav1 (Tl-elav1) showed expression in differentiated neurons of the CNS with continuous expression in the VNC, supporting evidence of a medullary cord, and refuting evidence of ontogenetic segmentation during formation of the nervous system. Thus, we conclude that sipunculans do not exhibit any signs of morphological segmentation during development.\",\"Include description in output citation\":0,\"Origin\":\"PubMed\"},\"facultyid\":\"C70204584\",\"status\":[{\"id\":1574,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2019,\"termid\":\"2019\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70204584\",\"attachments\":[],\"coauthors_list\":[\"Allan M Carrillo-Baltodano\",\"Michael J Boyle\",\"Mary E Rice\",\"N\\u00e9va P Meyer\"],\"sort_date\":\"2019-9-01\"},{\"activityid\":1578,\"fields\":{\"Type\":\"Presentations\",\"Title of Presentation\":\"The role of BMP signaling in early development of the spiralian Capitella teleta\",\"Conference \\\/ Meeting Name\":\"3rd Biennial meeting for the Pan-American Society for Evolutionary Developmental Biology\",\"Location of Conference \\\/ Meeting\":\"Miami, FL\",\"Month \\\/ Season\":\"August\",\"Year\":2019,\"Sponsoring Organization\":\"Pan-American 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