{"id":438,"date":"2024-12-13T10:31:07","date_gmt":"2024-12-13T15:31:07","guid":{"rendered":"https:\/\/www.golive.clarku.edu\/faculty\/profiles\/noel-lazo\/"},"modified":"2026-04-05T12:37:42","modified_gmt":"2026-04-05T16:37:42","slug":"noel-lazo","status":"publish","type":"cu_faculty","link":"https:\/\/www.clarku.edu\/faculty\/profiles\/noel-lazo\/","title":{"rendered":"Noel Lazo"},"content":{"rendered":"

Noel Lazo is a Professor in the Carlson School of Chemistry and Biochemistry. His laboratory is currently focusing on the proteolytic degradation and aggregation of proteins associated with late onset disorders including Alzheimer’s disease and related dementias and type 2 diabetes. A combination of spectroscopic (e.g., NMR spectroscopy), spectrometric (e.g., mass spectrometry), and biochemical (e.g., limited proteolysis) methods is used to decipher mechanisms for protein oligomerization and proteolytic degradation. Since joining Clark in 2006, Dr. Lazo has mentored over 50 graduate and undergraduate students, some of whom have co-authored publications – a good indicator of their motivation and dedication to contribute to research associated with disease.\u00a0\u00a0<\/p>\n

Courses Taught:
CHEM 101 (Introductory Chemistry I, Lecture)
CHEM 102 (Introductory Chemistry II, Lecture)
CHEM 289 (Research Methods: Circular Dichroism Spectroscopy)
BCMB 264 (Biophysical Chemistry, Lecture + Laboratory)
BCMB 266 (Biomolecular NMR Spectroscopy)
BCMB 271 (Biochemistry I, Lecture)
BCMB 297 (Amyloid Proteins)<\/span><\/p>\n","protected":false},"author":0,"featured_media":1909,"parent":0,"template":"","meta":{"cu_faculty_f180_userid":"C70170161","cu_faculty_first_name":"Noel","cu_faculty_last_name":"Lazo","cu_faculty_employment_status":"Full Time","cu_faculty_rank":"Professor","cu_faculty_position":"Professor","cu_faculty_phone":"","cu_faculty_email":"nlazo@clarku.edu","cu_faculty_location":"","cu_faculty_about":"

Noel Lazo is a Professor in the Carlson School of Chemistry and Biochemistry. His laboratory is currently focusing on the proteolytic degradation and aggregation of proteins associated with late onset disorders including Alzheimer's disease and related dementias and type 2 diabetes. A combination of spectroscopic (e.g., NMR spectroscopy), spectrometric (e.g., mass spectrometry), and biochemical (e.g., limited proteolysis) methods is used to decipher mechanisms for protein oligomerization and proteolytic degradation. Since joining Clark in 2006, Dr. Lazo has mentored over 50 graduate and undergraduate students, some of whom have co-authored publications - a good indicator of their motivation and dedication to contribute to research associated with disease.\u00a0\u00a0

Courses Taught:
CHEM 101 (Introductory Chemistry I, Lecture)
CHEM 102 (Introductory Chemistry II, Lecture)
CHEM 289 (Research Methods: Circular Dichroism Spectroscopy)
BCMB 264 (Biophysical Chemistry, Lecture + Laboratory)
BCMB 266 (Biomolecular NMR Spectroscopy)
BCMB 271 (Biochemistry I, Lecture)
BCMB 297 (Amyloid Proteins)<\/span><\/p>","cu_faculty_degrees":"Ph.D. in Chemistry, Solid-state NMR,<\/span> Texas A&M University, 1991","cu_faculty_cv":"","cu_faculty_links":"{\"Professional Website URL\":\"http:\\\/\\\/wordpress.clarku.edu\\\/nlazo\",\"ORCID ID\":\"https:\\\/\\\/orcid.org\\\/0000-0003-1769-7572\"}","cu_faculty_scholarly_interests":"","cu_faculty_scholarly_works":"[{\"activityid\":13244,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Differential Effects of A\\u03b2 Peptides on the Plasmin-Dependent Degradation of ApoE3 and ApoE4\",\"Journal Title\":\"ACS Chemical Neuroscience\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2025,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"16\",\"Issue Number \\\/ Edition\":\"6\",\"Page Number(s) or Number of Pages\":\"1227-1237\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"https:\\\/\\\/pubs.acs.org\\\/doi\\\/10.1021\\\/acschemneuro.5c00065\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":13244,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2025,\"termid\":\"2024\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Merc M Kemeh\",\"Anthony J Furnelli\",\"Noel Lazo\"],\"sort_date\":\"2025-1-01\"},{\"activityid\":11255,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Highly Toxic A\\u03b2 Begets More A\\u03b2\",\"Journal Title\":\"Neural Regeneration Research\",\"Series Title\":\"\",\"Month \\\/ Season\":\"\",\"Year\":2024,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"19\",\"Issue Number \\\/ Edition\":\"9\",\"Page Number(s) or Number of Pages\":\"1871-1872\",\"ISSN\":\"\",\"DOI\":\"doi: 10.4103\\\/1673-5374.390983. 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Lazo\"],\"sort_date\":\"2024-1-01\"},{\"activityid\":11256,\"fields\":{\"Type\":\"Other Media (social media, blogs, podcasts, etc)\",\"Title\":\"How A\\u03b2 peptides modulate insulin degradation in Alzheimer's and diabetes\",\"Episode Title\":\"\",\"Date Published\":\"2024-01-11\",\"Year\":2024,\"Platform\":\"Medicine Innovates \",\"CoAuthor\":null,\"URL\":\"https:\\\/\\\/medicineinnovates.com\\\/mechanism-of-action\\\/\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"Manual\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":11256,\"status\":\"Completed\\\/Published\",\"term\":\"Spring\",\"year\":2024,\"termid\":\"2023\\\/03\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Merc M. Kemeh\",\"Noel D. 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Lazo\"],\"sort_date\":\"2023-1-01\"},{\"activityid\":8649,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes\",\"Journal Title\":\"ACS Omega\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2022\",\"Year\":2022,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"7\",\"Issue Number \\\/ Edition\":\"28\",\"Page Number(s) or Number of Pages\":\"24757\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8649,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2022,\"termid\":\"2022\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Qiuchen Zheng\",\"Bethany Lee\",\"Micheal T. Kebede\",\"Valerie A. Ivancic\",\"Merc M. Kemeh\",\"Henrique Lemos Brito\",\"Donald E. Spratt\",\"Noel D. Lazo\"],\"sort_date\":\"2022--01\"},{\"activityid\":8650,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme\",\"Journal Title\":\"Antioxidants (Basel)\",\"Series Title\":null,\"Month \\\/ Season\":\"2021\",\"Year\":2021,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"10\",\"Issue Number \\\/ Edition\":\"9\",\"Page Number(s) or Number of Pages\":\"1342\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":null,\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8650,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2021,\"termid\":\"2021\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Qiuchen Zheng\",\"Micheal T. Kebede\",\"Bethany Lee\",\"Claire A. Krasinski\",\"Saadman Islam\",\"Liliana A. Wurfl\",\"Merc M. Kemeh\",\"Valerie A. Ivancic\",\"Charles E. Jakobsche\",\"Donald E. Spratt\",\"Noel D. Lazo\"],\"sort_date\":\"2021--01\"},{\"activityid\":8651,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides\",\"Journal Title\":\"Langmuir\",\"Series Title\":null,\"Month \\\/ Season\":\"2020\",\"Year\":2020,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"36\",\"Issue Number \\\/ Edition\":\"29\",\"Page Number(s) or Number of Pages\":\"8389\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":null,\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8651,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2020,\"termid\":\"2020\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Qiuchen Zheng\",\"Senegal N. Carty\",\"Noel D. Lazo\"],\"sort_date\":\"2020--01\"},{\"activityid\":8652,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Inhibition of the Self-Assembly of A\\u03b2 and of Tau by Polyphenols: Mechanistic Studies\",\"Journal Title\":\"Molecules\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2019\",\"Year\":2019,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"24\",\"Issue Number \\\/ Edition\":\"12\",\"Page Number(s) or Number of Pages\":\"2316\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8652,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2019,\"termid\":\"2019\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Qiuchen Zheng\",\"Micheal T. Kebede\",\"Merc M. Kemeh\",\"Saadman Islam\",\"Bethany Lee\",\"Stuart D. Bleck\",\"Liliana A. Wurfl\",\"Noel D. Lazo\"],\"sort_date\":\"2019--01\"},{\"activityid\":8653,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Resveratrol Sustains Insulin-Degrading Enzyme Activity toward A\\u03b242\",\"Journal Title\":\"ACS Omega\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2018\",\"Year\":2018,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"3\",\"Issue Number \\\/ Edition\":\"10\",\"Page Number(s) or Number of Pages\":\"13275\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8653,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2018,\"termid\":\"2018\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Claire A. Krasinski\",\"Valerie A. Ivancic\",\"Qiuchen Zheng\",\"Donald E. Spratt\",\"Noel D. Lazo\"],\"sort_date\":\"2018--01\"},{\"activityid\":8654,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme\",\"Journal Title\":\"Biosci Rep\",\"Series Title\":null,\"Month \\\/ Season\":\"2018\",\"Year\":2018,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"38\",\"Issue Number \\\/ Edition\":\"6\",\"Page Number(s) or Number of Pages\":\"BSR20181416\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":null,\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8654,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2018,\"termid\":\"2018\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Valerie A. Ivancic\",\"Claire A. Krasinski\",\"Qiuchen Zheng\",\"Rebecca J. Meservier\",\"Donald E. Spratt\",\"Noel D. Lazo\"],\"sort_date\":\"2018--01\"},{\"activityid\":8655,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"The Longest Amyloid-\\u03b2 Precursor Protein Intracellular Domain Produced with A\\u03b242 Forms \\u03b2-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme\",\"Journal Title\":\"ACS Chem Neurosci\",\"Series Title\":\"\",\"Month \\\/ Season\":\"2018\",\"Year\":2018,\"Publisher\":\"\",\"Publisher City and State\":\"\",\"Publisher Country\":\"\",\"Volume\":\"9\",\"Issue Number \\\/ Edition\":\"12\",\"Page Number(s) or Number of Pages\":\"2892\",\"ISSN\":\"\",\"DOI\":\"\",\"CoAuthor\":null,\"URL\":\"\",\"Description\":\"\",\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8655,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2018,\"termid\":\"2018\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Claire A. 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Lazo\"],\"sort_date\":\"2018--01\"},{\"activityid\":8656,\"fields\":{\"Type\":\"Articles in Refereed Journals\",\"Title\":\"Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid\",\"Journal Title\":\"J Phys Chem B\",\"Series Title\":null,\"Month \\\/ Season\":\"2018\",\"Year\":2018,\"Publisher\":null,\"Publisher City and State\":null,\"Publisher Country\":null,\"Volume\":\"122\",\"Issue Number \\\/ Edition\":\"8\",\"Page Number(s) or Number of Pages\":\"2323\",\"ISSN\":null,\"DOI\":null,\"CoAuthor\":null,\"URL\":null,\"Description\":null,\"Include description in output citation\":0,\"Origin\":\"RIS\"},\"facultyid\":\"C70170161\",\"status\":[{\"id\":8656,\"status\":\"Completed\\\/Published\",\"term\":\"Fall\",\"year\":2018,\"termid\":\"2018\\\/01\",\"listingorder\":6,\"completionorder\":6}],\"userid\":\"C70170161\",\"attachments\":[],\"coauthors_list\":[\"Qiuchen Zheng\",\"Noel D. 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