Faculty Biography

Joseph K. H. Tang

Joseph K. H. Tang, Ph.D.

Assistant Professor, Carlson School of Chemistry
Adjunct Assistant Professor of Biology

Department of Chemistry
Department of Biology
Clark University
Worcester, MA 01610-1477

Office: S226, Sackler Sciences Center
Phone: 508-793-7536
Email: jtang@clarku.edu

Curriculum Vitae

Ph.D. student position available

B.S., Tamkang University, Taipei, Taiwan, 1990
M.S., National Taiwan University, Taipei, Taiwan, 1992
Ph.D., University of Wisconsin-Madison, Madison, Wisconsin, 2002
Postdoctoral Researcher, Department of Biochemistry, School of Medicine, Stanford University, 2003-2004
Joint Postdoctoral Fellow, Genomic Research Center, Academia Sinica, Taiwan, and Departments of Chemistry and Biochemistry, The Ohio State University, 2004-2008
Research Scientist, Departments of Biology and Chemistry, Washington University in St. Louis 2008-2011
Biochemistry, Enzymology, Metabolic Pathways

Current Research & Teaching

My research focuses on three directions:

(A) Detailed understanding of structure-function relationships of bio-medically and/or bio-energetically relevant enzymes using a wide variety of bioorganic, molecular biological, biochemical, and biophysical techniques.

(B) Explore the metabolic pathways for energy storage and conversion in phototrophic microbes using genomics, transcriptomics, metabolomics, biochemical, and physiological approaches.

(C) Develop bio-hybrid devices for effective light harvesting.

Selected Publications

Tang, J.K.H., You, L., Blankenship, R.E., and Tang, Y.J. (2012) Recent advances in mapping novel microbial metabolisms through 13C isotopic fingerprints. J. R. Soc. Interface. 9, 2767-2780

O’Dell, W.B., Beatty, K.J., Tang, J.K.H., Blankenship, R.E., Urban, V.S. and O’Neill, H.M. (2012) Sol–gel entrapped light harvesting antennae: immobilization and stabilization of chlorosomes for energy harvesting. J. Mater. Chem. 22, 22582–22591

Tang, K.H. and Blankenship, R.E. (2012) Neutron and light scattering studies of light-harvesting photosynthetic antenna complexes. Photosynth. Res. 111, 205-217

Tang, K.H.*, Tang, Y.J. and Blankenship, R.E.* (2011) Carbon metabolism pathways in phototrophic bacteria and their broader evolutionary implications. Front. Microbio. 2, 165.

Tang, K.H., Zhu, Y., Urban, V.S., Collins, A.M., Biswas, P. and Blankenship, R.E. (2011) Temperature and ionic strength effects on the chlorosome light-harvesting antenna complex. Langmuir. 27, 4816-4828.

Tang, K.H., Zhu, Y., Urban, V.S., Collins, A.M., Biswas, P. and Blankenship, R.E. (2011) Temperature and ionic strength effects on the chlorosome light-harvesting antenna complex. Langmuir. 27, 4816-4828.

Tang, K.H., Barry, K., Chertkov, O., Dalin, E., Han, C.S., Hauser, L.J., Honchak, B.M., Karbach, L.E., Lapidus, A., Larimer, F.W., Mikhailova, N., Pitluck, S., Pierson, B.K. and Blankenship, R.E. (2011) Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. BMC Genomics. 12, 334 (Feature Article)

Tang, K.H., Feng, X., Zhuang, W.Q., Alvarez-Cohen, L., Blankenship, R.E. and Tang, Y.J. (2010) Carbon flow of heliobacteria is more related to Clostridia than to the green sulfur bacteria. J. Biol. Chem. 285, 35104-35112 (Corresponding author).

Feng, X., Tang, K.H., Blankenship, R.E. and Tang, Y.J. (2010) Metabolic flux analysis of the mixotrophic metabolisms in the green sulfur bacterium Chlorobaculum tepidum. J. Biol. Chem. 285, 39544-39550 (contributed equally to the work).

Tang, K.H. and Blankenship, R.E. (2010) Both forward and reverse TCA cycles operate in the green sulfur bacteria. J. Biol. Chem. 285, 35844-35854.

Tang, K.H., Urban, V.S., Wen, J., Xin, Y. and Blankenship, R.E. (2010) SANS investigation of the photosynthetic machinery of Chloroflexus aurantiacus. Biophys. J. 99, 2398-2407.

Tang, K.H., Wen, J., Li, X. and Blankenship, R.E. (2009) Role of the AcsF protein in Chloroflexus aurantiacus. J. Bacteriol. 191, 3580-3587.

Tang, K.H., Mansoorabadi, S., Reed, G.H. and Frey, P.A. (2009) Suicide inhibition and radical triplet intermediates in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. Biochemistry 48, 8151-8160.

Tang, K.H., Niebuhr, M., Tung, C.S., Chen, S.C., Chou, C.C. and Tsai, M.D. (2008) Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways. Nucleic Acids Res. 36, 2948-2957 (Faculty of 1000) (Corresponding author).

Tang, K.H., Niebuhr, M., Aulabaugh, A. and Tsai, M.D. (2008) Solution structures of 2:1 and 1:1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle x-ray scattering. Nucleic Acids Res. 36, 849-860.

Tang, K.H. and Tsai, M.D. (2008) Structure and Function of 2:1 DNA polymerase-DNA complexes. J. Cell Physiol. 216, 315-320.

Tang, K.H., Liao, F.Y. and Tsai, Y.M. (2005) The study of intramolecular tandem radical cyclizations of acylsilanes with radicalphiles attached on silicon. Tetrahedron 61, 2037-2045.

Berkovitch, F, Behshad, E., Tang, K.H., Enns, E.A., Frey, P.A. and Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proc Natl Acad Sci U S A 101, 15870-15875.