Computational Science

Professor Lazo

Noel Lazo, Ph.D.

Associate Professor Carlson School of Chemistry
Adjunct Associate Professor, Department of Biology
Carlson School of Chemistry
Department of Biology
Clark University
Worcester, MA 01610

Office: S335, Sackler Sciences Center
Phone: 508-793-7602
Email: nlazo@clarku.edu

Curriculum Vitae
Research Lab Website


 

Education

Ph.D. Texas A&M University, 1991
M.S. SUNY at Syracuse
B.S. University of the Philippines

Research Summary

Research in the Lazo Lab is focused on the biophysics of misfolding and self-assembly of proteins associated with disease. Proteins of interest include the amyloid β-protein in Alzheimer's disease, islet amyloid polypeptide associated with type 2 diabetes, the prion protein in various forms of prionoses, and skin proteins linked to epidermolysis bullosa, a disease characterized by skin blistering following little or no trauma. A combination of biophysical and biochemical methods including NMR spectroscopy and limited proteolysis/mass spectrometry is used to elucidate the early events of protein misfolding and self-assembly.

Recent Publications:

Robbins KJ, Liu G, Selmani V, Lazo ND. Conformational analysis of thioflavin T bound to the surface of amyloid fibrils (2012). Langmuir, 28,16490-16495

Liu, G, Gaines JC, Robbins KJ, Lazo ND. Kinetic profile of amyloid formation in the presence of an aromatic inhibitor by nuclear magnetic resonance (2012). ACS Med. Chem Lett. 3, 856-859

Liu G, Robbins KJ, Sparks S, Selmani V, Bilides K, Lazo ND. Helix dipole effects in peptide self-assembly to amyloid (2012). Biochemistry, 51(20): 4167-4174.

Sparks S, Liu G, Robbins KJ, Lazo ND. Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling a-helix (2012). Biochem. Biophys. Res. Commun. 422(4): 551-555

Robbins KJ, Lin G, and Lazo ND. Detection of strongly bound thioflavin T species in amyloid fibrils by ligand-detected 1H NMR (2011).J. Phys. Chem. Lett. 2, 735-740


Lui G, Prabhakar A, Aucoin D, Simon M, Sparks S, Robbins KJ, Sheen A, Petty SA, and Lazo ND. Mechanistic studies of peptide self-assembly: Transient α-helices to stable β-sheets (2010). J. Am. Chem. Soc. 132, 18223-18232