Clark University Academics & Faculty
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Tel: 508-793-7711 • academicaffairs@clarku.edu

Biochemistry and Molecular Biology
Programs
The Biochemistry and Molecular Biology Department offers a major, minor and electives for undergraduates, and an accelerated B.A./M.A. fifth-year free option for qualified Clark undergraduates. The fifth year for the M.A. is taken through either the biology or chemistry department.

Recent Honors Thesis Titles

2005

Elysia Alvarez   Honors advisor: D. Nelson
Computational Analysis of the Interaction of the Anthrax Lethal Factor Exotoxin with Peptide Substrate Analogs and with the anthrax Protective Antigen "Pre-Pore"

Mary Badon   Honors advisors: D. Larochelle (Clark), C. Field and T. Mitchison (Harvard Medical School)
Analysis of Centrosome Function in Cell Division and Characterization of Small Molecule Inhibitors

Kim Leblanc   Honors advisor: UMass
Attachment of the Lyme Disease Spirochete to Mammalian Host Cells as Mediated by BBK032

Adam McPherson   Honors advisor: UMass
Analysis of factors associated with Pbp1p in the post-transcriptional control of gene expression

Nicole Mills   Honors advisor: J. Thackeray
Knocking out a Potential Tyrosine Phosphorylation Site in Drosophila PLC-gamma

James Vecchione   Honors advisor: D. Larochelle
Understanding the Pats1 Gene and its Involvement in the Molecular Regulation of Cytokinesis

Boyan Yordanov   Honors advisor: S. Huo
Initial conformational changes of transthyretin triggering amyloid formation: Molecular dynamics simulation under low pH conditions

2004

Juliana DeMelfi   Honors advisor: UMass
An Analysis of EBV-Specific CD8+ T Cell Receptor Repertoire Interactions with an HLA-A*0201 / BMLF-1 Epitope

Kriti Gaur   Honors advisor: D. Robertson
Characterization of enzyme Glutamine Synthetase in the dinoflagellate Alexandrium tamerense

Stephanie Roy   Honors advisor: D. Nelson
Docking of 3Õ-deoxy-ATP into the Adenylyl Cyclase Active Site of Wild-Type and Mutant Anthrax Edema Factor Variants: An Analysis Utilizing GRID-21, Simple Molecular Mechanics with InsightII and GRASP Surface Electrochemical Potential.

Zu Shen   Honors advisor: D. Thurlow
Kinetic Studies of ATP/CTP tRNA Nucleotidyltransferase from M. jannaschi

Miguel Stein   Honors advisor: D. Robertson
Effects of Extracellular Nitrate on the Regulation of Glutamine Synthatase II2 in Skeletonema Costatum

2003

Sarah Deroko   Honors advisor: D. Larochelle
Characterization of Pats1, a novel gene required for cytokinesis in Dictyostelium

Matthew Evans   Honors advisor: UMass
Identification of Point Mutants in Pab1p that Specifically Eliminate Interaction with the Positive Activator of Poly(A) Nuclease, Pan3p

Jinal Patel    Honors advisor: D. Thurlow
A kinetic study of the Drosophila melanogaster whole and truncated CCA-adding enzymes

Branka Stancevic   Honors advisor: D. Thurlow
Site-directed mutagenesis of M. janaschii ATP/CTP tRNA nucleotidyltransferase

Bradford Stanley   Honors advisor: Stryker Biotech
Uncovering the Origins of Heterogeneity in a Recombinant Protein Product: Analysis of recombinant human Osteogenic Protein-1 by two-dimensional gel electrophoresis

2002

Nate Agrin   Honors advisor: UMass
Mapping Protein Interactions in the Regulatory Network Controlling Pab1p-Dependant Poly(A) Nuclease

Megan Albert   Honors advisor: D. Thurlow
Mutants and models of nucleotidyltransferase

Lored Asllani   Honors advisor: D. Thurlow
Purification of tRNA nucleotidyltransferase for structural studies

Frances Austin    Honors advisor: J. Thackeray
Screening for Genes on the X-Chromosome Affecting Geotaxis in Drosophila melanogaster

Nathan Berkowitz    Honors advisor: D. Hibbett
RT-PCR Amplification of Fungal Mn Peroxidase mRNAs for Phylogenetic Studies

Jennifer Pacheco   Honors advisor: UMass
RNA Recognition Motifs in Overexpression of Yeast Poly (A)-Binding protein

Erika Person   Honors advisor: D. Nelson
Molecular dynamics of single-site variants of Human superoxide dismutase linked to Lou GehrigÕs Disease

Craig Stone   Honors advisor: UMass
Mechanism of Early Endosome Tethering by Rab 5, EEA1, and PtdIns(3)P

Joshua Suhl   Honors advisor: J. Thackeray
Mutating the PLC-gamma SH2 domains in Drosophila melanogaster

2001

Kamau Fahie   Honors advisor: D. Nelson
Molecular dynamics simulation analysis of the metal binding properties of a non-conservative mutational variant of the Silver Hake parvalbumin (Isoform B) whole protein and functional fragments

Nyawira Gikunju   Honors advisor: D. Thurlow
Site-directed mutagenesis of the ATP/CTP:tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae

Christine Whittish   Honors advisor: UMass
Does Bloom Syndrome Helicase Affect Class Switch Recombination?


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