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Somatic and Molecular Cell Genetics

Student Research Projects

In addition to participating in the class research project, each student in this course is required to conduct an independent research project, either related to the class project or not. Below are some general descriptions of some of the independent research projects that students worked on in the spring 2004 semester.

Sebastian Mana-Capelli's project goal was to establish a primary cell line using chondrocyte of mice that have a syndrome similar to a syndrome that humans have. He is trying to establish this primary cell line and compare chondrocytes with this mutation to normal chondrocytes.

Miguel Stein worked on two separate projects. One of them is to generate the plasmid containing the VSV-G retroviral gene, which is used to transfect the packaging cell line which is used to produce a retroviral cloning vector. He'll use that to infect other cells. In the second project, he hoped to determine if the packaging and production of the virus was less successful by looking at the medium of the cells which were transfected through the plasmid that he amplified.

Tim Markantes designed a Web site where class members can put the results from the class project about a neomycin-resistant amphibian cell line. It will also be a place for class members to post results from their independent projects.

Max Somberg looked at different transfection methods, or methods of incorporating foreign DNA or foreign genes into cells. He is testing one of two methods: calcium phosphate precipitation in order to allow DNA to be taken up by cells.

Shannon Joyce is looking at different transfection methods, doing transfection of the X laevis frog line with A6 cells.

Abigail Rollings looked at the patentability of cell lines. She was in contact with researchers at MIT trying to get a cell line at Clark that the class researched at the beginning of the semester. By examining legal precedents, she was also trying to determine if that cell line was patentable after being modified by Clark students.

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Professor Tim Lyerla

Abigail Rollings
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Max Somberg '04

Sarah Deroko'03

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